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首页> 外文期刊>Surgical neurology >Radio-guided brain tumorectomy using a gamma detecting probe and a mobile solid-state gamma camera.
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Radio-guided brain tumorectomy using a gamma detecting probe and a mobile solid-state gamma camera.

机译：使用伽马探测探头和移动固态伽马相机进行的放射性脑肿瘤切除术。

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BACKGROUND: We herein report a technique to distinguish brain tumors from normal brain tissue during surgery using a gamma probe and a solid-state mobile gamma camera after (99m)Tc-hexakis-2-methoxy-isobutyl-isonitrile ((99m)Tc-MIBI) is administered to patients immediately before operation. METHODS: We examined 13 patients with brain tumors. Before the operation, (99m)Tc-MIBI single photon emission computed tomography (SPECT) was performed to assess accumulation in the tumors. On the day of the operation, (99m)Tc-MIBI was administered intravenously and craniotomy for tumor resection was performed. During the operation, the tumor was localized with a gamma probe and preremoval scintigraphy images were taken with a mobile gamma camera. After tumor resection was completed, residual tumors were confirmed using it again. We compared accumulation found in the preoperative SPECT images and intraoperative scintigraphy images, performed a histologic examination of adjacent tissues, and measured the dose the personnel was exposed to per operation. RESULTS: In all patients, tumors were confirmed by a gamma probe and scintigraphy during the operation. Intraoperative accumulation in tumors was significantly related to accumulation found in the preoperative (99m)Tc-MIBI SPECT images. In 9 out of 13 patients, accumulation disappeared in the postremoval scintigraphy images, and no tumor tissue was found by histologic examination. Residual tumor tissue was found in 4 patients. Average exposure of the personnel per operation was 22.9 +/- 4.0 microSv. CONCLUSION: Resection of brain tumors with a gamma probe and a mobile gamma camera was very useful since the area to be removed was easily identified and residual tumors could be detected.
机译：背景：我们在此报告了一种技术，该技术在（99m）Tc-己基-2-甲氧基-二甲氧基-异丁基-异腈（（99m）Tc-）之后，使用伽马探针和固态移动伽马相机在手术过程中将脑肿瘤与正常脑组织区分开手术前立即将MIBI）给予患者。方法：我们检查了13例脑肿瘤患者。手术前，进行（99m）Tc-MIBI单光子发射计算机断层扫描（SPECT）评估肿瘤中的蓄积。在手术当天，静脉注射（99m）Tc-MIBI并开颅手术以切除肿瘤。手术期间，用伽马探针定位肿瘤，并用移动式伽马相机拍摄切除前的闪烁显像图像。肿瘤切除完成后，再次使用它确认残留肿瘤。我们比较了术前SPECT图像和术中闪烁显像图像中发现的积聚，对相邻组织进行了组织学检查，并测量了每个手术人员所要承受的剂量。结果：所有患者在手术过程中均被伽玛探针和闪烁显像证实。术中肿瘤的积累与术前（99m）Tc-MIBI SPECT图像中发现的积累显着相关。 13例患者中有9例在切除后闪烁显像图像中消失，并且通过组织学检查未发现肿瘤组织。在4名患者中发现了残留的肿瘤组织。每次操作人员的平均暴露为22.9 +/- 4.0 microSv。结论：用伽马探针和移动式伽马相机切除脑肿瘤非常有用，因为要切除的区域很容易识别，并且可以检测到残留的肿瘤。

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