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首页> 外文期刊>Biomaterials >The effect of the encapsulation of bacteria in redox phospholipid polymer hydrogels on electron transfer efficiency in living cell-based devices
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The effect of the encapsulation of bacteria in redox phospholipid polymer hydrogels on electron transfer efficiency in living cell-based devices

机译：氧化还原磷脂聚合物水凝胶中细菌的包裹对基于活细胞的设备中电子转移效率的影响

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摘要

Development of living cell-based devices holds great promise in many biomedical and industrial applications. To increase our understanding of the process, we investigated the biological and electrochemical properties of a redox phospholipid polymer hydrogel containing an electron-generating bacteria (Shewanella oneidensis MR-1). A water-soluble and amphiphilic phospholipid polymer, poly(2-methacryloyloxyethyl phosphorylcholine-. co-. n-butyl methacrylate-. co-. p-vinylphenylboronic acid-. co-vinylferrocene) (PMBVF), was our choice for incorporation into a hydrogel matrix that promotes encapsulation of bacteria and acts as an electron transfer mediator. This hydrogel formed spontaneously and encapsulated Shewanella in three-dimensional structures. Visual analysis showed that the encapsulated Shewanella maintained viability and metabolic activity even after long-term storage. Cyclic voltammetry measurement indicated that the PMBVF/poly(vinyl alcohol) (PMBVF/PVA) hydrogel had stable and high electron transfer efficiency. Amperometric measurement showed that the hydrogel could maintain the electron transfer efficiency even when Shewanella was encapsulated. Thus, the PMBVF/PVA hydrogel not only provides a mild environment for long-term bacterial survival but also maintains electron transfer efficiency from the bacteria to the electrode. We conclude that hydrogel/bacteria hybrid biomaterials, such as PMBVF/PVA/. Shewanella, may find application in the fabrication of living cell-based devices.
机译：在许多生物医学和工业应用中，基于活细胞的设备的开发都具有广阔的前景。为了增进我们对该过程的了解，我们研究了含有电子产生细菌（Shewanella oneidensis MR-1）的氧化还原磷脂聚合物水凝胶的生物学和电化学特性。水溶性和两亲性磷脂聚合物，聚（2-甲基丙烯酰氧基乙基磷酰胆碱-.-甲基丙烯酸正丁酯-.-对-乙烯基苯基硼酸-.-乙烯基二茂铁）（PMBVF）是我们选择并入促进细菌包封并充当电子传递介质的水凝胶基质。该水凝胶自发形成并以三维结构封装希瓦氏菌。视觉分析表明，包封的希瓦氏菌即使在长期保存后仍保持活力和代谢活性。循环伏安法测量表明，PMBVF /聚乙烯醇（PMBVF / PVA）水凝胶具有稳定且高电子转移效率。安培测量表明，即使将希瓦氏菌包封，水凝胶也可以保持电子转移效率。因此，PMBVF / PVA水凝胶不仅为细菌长期生存提供了温和的环境，而且还保持了从细菌到电极的电子转移效率。我们得出的结论是，水凝胶/细菌杂化生物材料，例如PMBVF / PVA /。 Shewanella可能会在基于活细胞的设备的制造中找到应用。

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