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CD30-Negative cutaneous T-Cell lymphomas other than mycosis fungoides

机译:CD30阴性的皮肤真菌性T细胞淋巴瘤

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Cutaneous T-cell lymphomas (CTCLs), other than mycosis fungoides/Sézary syndrome and the group of cutaneous CD30+ lymphoproliferative disorders, are rare. These include subcutaneous panniculitis-like T-cell lymphoma (SPTCL); extranodal natural killer/T-cell lymphoma, nasal type; primary cutaneous peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS); and rare subtypes of PTCL, NOS. Apart from SPTCL and primary cutaneous CD4-positive small-medium pleomorphic T-cell lymphoma, these lymphomas have in common aggressive clinical behavior and poor prognosis. Differentiation between these different types of CTCL may be difficult and requires integration of histopathologic findings with clinical data and the results of phenotypic and often molecular genetic studies.
机译:除真菌病/塞氏病综合征和皮肤CD30 +淋巴增生性疾病外,皮肤性T细胞淋巴瘤(CTCL)很少。这些包括皮下脂膜炎样T细胞淋巴瘤(SPTCL);鼻外型自然杀手/ T细胞淋巴瘤;皮肤原发性外周T细胞淋巴瘤,未另作规定(PTCL,NOS);以及PTCL,NOS的罕见亚型。除SPTCL和原发性皮肤CD4阳性小中型多形性T细胞淋巴瘤外,这些淋巴瘤具有共同的侵袭性临床行为和不良预后。这些不同类型的CTCL之间的区分可能很困难,并且需要将组织病理学发现与临床数据以及表型和分子遗传学研究的结果相结合。

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