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The Basics of Renal Allograft Pathology

机译:肾脏同种异体移植病理学基础

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Renal allograft biopsy provides critical information in the management of renal transplant patients, and must be analyzed in close collaboration with the clinical team. The histologic correlates of acute T-cell mediated rejection are interstitial inflammation, tubulitis, and endothelialitis; polyomavirus nephropathy is a potential mimic. Evidence of antibody-mediated rejection includes C4d deposition; morphologic acute tissue injury; and donor specific antibodies. Acute tubular injuryecrosis is a reversible cause of impaired graft function, especially in the immediate post-transplant period. Drug toxicity, recurrent disease, chronic injury, and other entities affecting both native and transplant kidneys must also be evaluated.
机译:同种异体肾活检为肾移植患者的治疗提供了重要信息,必须与临床团队密切合作进行分析。急性T细胞介导的排斥反应的组织学相关性是间质性炎症,肾小管炎和内皮炎。多瘤病毒肾病是一种潜在的模仿物。抗体介导的排斥反应的证据包括C4d沉积;形态学上的急性组织损伤;和供体特异性抗体。急性肾小管损伤/坏死是造成移植物功能受损的可逆原因,尤其是在移植后立即。还必须评估药物毒性,复发性疾病,慢性损伤以及影响天然肾脏和移植肾脏的其他实体。

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