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首页> 外文期刊>Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer >Body weight and fat-free mass changes in a cohort of patients receiving chemotherapy.
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Body weight and fat-free mass changes in a cohort of patients receiving chemotherapy.

机译：一群接受化疗的患者的体重和无脂肪质量变化。

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摘要

PURPOSE: Malnutrition is prevalent in cancer patients and it can become even greater during its treatment. The purpose of the present study is to verify changes in the fat-free mass (FFM) and body weight (BW) in cancer patients during chemotherapy treatment and to identify their significant determinants. METHODS: In a longitudinal study of 174 patients starting a chemotherapy protocol, bioelectrical impedance analysis (BIA) was used to estimate FFM and the nutritional assessment by patient-generated subjective global assessment. BW and FFM changes have been calculated and their significant determinants were identified after a multivariate analysis. RESULTS: Malnutrition was found in 23% of the patients at the admission. After a multivariate analysis, a significant BW change was found during the treatment in patients submitted to previous/adjuvant and palliative chemotherapy (weight gain of 4.15% and 2.23%, respectively, p = 0.05) and a significant FFM loss (7.61%, p < 0.01) in patients with severe malnutrition at admission. CONCLUSIONS: Only the chemotherapy protocol and initial nutritional state had a significant influence in BW and FFM changes during the chemotherapy. BIA may contribute to other methods of nutritional assessment, in order to detect modifications in body composition even in the absence of BW changes.
机译：目的：营养不良在癌症患者中很普遍，在治疗过程中甚至可能变得更加严重。本研究的目的是验证化疗期间癌症患者的无脂肪质量（FFM）和体重（BW）的变化，并确定其重要决定因素。方法：在一项对174位开始化疗方案的患者的纵向研究中，生物电阻抗分析（BIA）用于通过患者产生的主观整体评估来评估FFM和营养评估。已计算出体重和FFM变化，并在进行多变量分析后确定了其重要决定因素。结果：入院时发现23％的患者营养不良。经过多变量分析，在接受过先前/辅助和姑息化疗的患者的治疗期间，发现体重显着改变（体重增加分别为4.15％和2.23％，p = 0.05）和明显的FFM损失（7.61％，p） <0.01）入院时严重营养不良的患者。结论：仅化疗方案和初始营养状态对化疗期间体重和FFM的变化有显着影响。 BIA可能有助于其他营养评估方法，以便即使在没有体重变化的情况下也能检测出身体成分的变化。

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