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首页> 外文期刊>Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer >Physical activity for men receiving androgen deprivation therapy for prostate cancer: benefits from a 16-week intervention.
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Physical activity for men receiving androgen deprivation therapy for prostate cancer: benefits from a 16-week intervention.

机译：接受雄激素剥夺疗法治疗前列腺癌的男性的体育锻炼：受益于16周的干预。

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GOALS OF WORK: Prostate cancer patients receiving androgen deprivation therapy (ADT) are vulnerable to a number of potentially debilitating side effects, which can significantly impact quality of life. The role of alternate therapies, such as physical activity (PA), in attenuating these side effects is largely understudied for such a large population. Thus, the purpose of this study was to investigate the effects of PA intervention for men receiving ADT on PA behavior, quality of life, and fitness measures. PATIENTS AND METHODS: One hundred participants were randomized into an intervention (n = 53) or a wait-list control group (n = 47), with 11 dropping out of the intervention group and 23 dropping out of the wait-list control group prior to post-testing. The intervention consisted of both an individually tailored home-based aerobic and light resistant training program and weekly group sessions. PA, quality of life, fitness, and physiological outcomes were assessed pre and post the 16-week intervention. RESULTS: Significant increases in PA, supported by changes in girth measures and blood pressure, support the beneficial impact of the intervention. Positive trends were also evident for depression and fatigue. However, due to the high dropout rate, these results must be interpreted with caution. CONCLUSIONS: PA effectively attenuates many of the side effects of ADT and should be recommended to prostate survivors as an alternate therapy. Determining the maintenance of this behavior change will be important for understanding how the long-term benefits of increased activity levels may alleviate the late effects of ADT.
机译：工作目标：接受雄激素剥夺疗法（ADT）的前列腺癌患者容易受到许多可能使人衰弱的副作用的影响，这可能会严重影响生活质量。对于这么大的人群，很大程度上研究了替代疗法（例如体育锻炼（PA））在减轻这些副作用方面的作用。因此，本研究的目的是调查接受ADT的男性进行PA干预对PA行为，生活质量和健身指标的影响。患者与方法：将一百名参与者随机分为一个干预组（n = 53）或一个等待名单对照组（n = 47），其中有11个参与者退出干预小组，有23个参与者退出等待名单对照组。进行后期测试。干预措施包括个人量身定制的家庭有氧和耐光训练计划以及每周的小组会议。在16周的干预前后，评估了PA，生活质量，健康状况和生理结果。结果：围产措施和血压的变化支持了PA的显着增加，支持了干预措施的有益效果。抑郁和疲劳的积极趋势也很明显。但是，由于辍学率很高，因此必须谨慎解释这些结果。结论：PA可有效减轻ADT的许多副作用，应推荐前列腺生存者作为替代疗法。确定这种行为改变的维持对于了解增加活动水平的长期益处如何减轻ADT的后期影响至关重要。

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