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首页> 外文期刊>Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer >Low-dose granisetron for prophylaxis of acute chemotherapy-induced nausea and vomiting: a pilot study.
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Low-dose granisetron for prophylaxis of acute chemotherapy-induced nausea and vomiting: a pilot study.

机译：低剂量格拉司琼预防急性化疗引起的恶心和呕吐：一项前瞻性研究。

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OBJECTIVES: Chemotherapy-induced nausea and vomiting (QTNV) are very uncomfortable symptoms for patients with cancer, which can be circumvented in most of them with drug combinations containing serotonin receptor antagonists (5-HT3 receptor antagonists) such as granisetron. In an attempt to decrease costs of QTNV prophylaxis, we studied a lower dose regimen of granisetron. PATIENTS AND METHODS: Sixty patients with cancer scheduled to receive moderately/highly emetogenic chemotherapy were pretreated 1 h before with 0.5 mg granisetron p.o. combined with dexamethasone 20 mg i.v. RESULTS: We observed complete control for nausea, vomiting, and nausea and vomiting in 78% [95% confidence interval (CI), 67-89%], 61% (95% CI, 47.5-74.5%), and 58% (95% CI, 44.3-71.7%) of the patients, respectively. This regimen was very well tolerated; headache (35%), xerostomia (11%), and constipation (5%) were the most frequent adverse symptoms reported. CONCLUSIONS: The regimen with lower dose granisetron is effective for acute QTNV prophylaxis and offers a cheaper alternative for QTNV control. We feel that these encouraging results should be confirmed in a randomized comparative trial.
机译：目的：化疗引起的恶心和呕吐（QTNV）对于癌症患者来说是非常不舒服的症状，在大多数患者中，可以通过使用含有5-羟色胺受体拮抗剂（5-HT3受体拮抗剂）的药物组合（例如格拉司琼）来避免这些症状。为了降低QTNV预防费用，我们研究了Granisetron的低剂量方案。患者与方法：60名计划接受中度/高度呕吐化疗的癌症患者在接受0.5 mg granisetron p.o的治疗前1小时进行了治疗。结合地塞米松20毫克静脉注射结果：我们观察到恶心，呕吐，恶心和呕吐的完全控制率分别为78％[95％置信区间（CI），67-89％]，61％（95％CI，47.5-74.5％）和58％（ 95％CI，44.3-71.7％）。这种方案的耐受性很好。头痛（35％），口干（11％）和便秘（5％）是最常见的不良症状。结论：较低剂量的Granisetron方案可有效预防QTNV，并为QTNV控制提供了更便宜的选择。我们认为这些令人鼓舞的结果应在随机比较试验中得到证实。

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