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首页> 外文期刊>Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer >Fatigue in cancer patients is not related to changes in oxyhaemoglobin dissociation.
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Fatigue in cancer patients is not related to changes in oxyhaemoglobin dissociation.

机译：癌症患者的疲劳与氧合血红蛋白解离的变化无关。

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BACKGROUND: There is only a weak association between the degree of anaemia and severity of fatigue in cancer patients. It has been hypothesised that there may be functional changes in the erythrocytes or haemoglobin of cancer patients and that this may result in fatigue even in the presence of a "normal" or "low normal" haematocrit. PURPOSE: The purpose of the study was to investigate the relationship between oxyhaemoglobin dissociation and fatigue in patients with cancer and to compare oxyhaemoglobin dissociation between cancer patients and healthy controls. PATIENTS AND METHODS: A heterogeneous group of patients with cancer (n = 22) and a control group of healthy subjects without cancer (n = 28) were studied. Subjects completed a fatigue questionnaire [the Functional Assessment of Cancer Therapy Fatigue (FACT-F) scale] and provided 10 ml of blood for analysis. Specimens were analysed to determine the partial pressure of oxygen at which 50% haemoglobin saturation occurred (P50) and were also sent for routine haematological and biochemical analysis. RESULTS: No differences were found between the oxyhaemoglobin dissociation curves of patients with cancer and controls. There was no significant correlation between fatigue severity and P50 in either patients or controls. CONCLUSION: There is no evidence to support the hypothesis that cancer-related fatigue is due to differences in oxyhaemoglobin dissociation.
机译：背景：贫血程度与癌症患者的疲劳程度之间只有很弱的联系。假设癌症患者的红细胞或血红蛋白可能存在功能改变，即使存在“正常”或“低正常”血细胞比容，这也可能导致疲劳。目的：本研究的目的是研究癌症患者氧合血红蛋白解离与疲劳之间的关系，并比较癌症患者和健康对照者之间的氧合血红蛋白解离。患者与方法：研究了异种癌症患者组（n = 22）和健康受试者无癌症的对照组（n = 28）。受试者完成了一份疲劳调查表[癌症治疗疲劳功能评估（FACT-F）量表]，并提供了10 ml血液用于分析。分析样品以确定氧分压，在该分压下发生50％的血红蛋白饱和度（P50），并且还送去进行常规的血液学和生化分析。结果：癌症患者和对照组的氧合血红蛋白解离曲线之间没有差异。在患者或对照组中，疲劳严重程度与P50之间无显着相关性。结论：没有证据支持这一假设，即与癌症相关的疲劳是由于氧合血红蛋白解离的差异所致。

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