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首页> 外文期刊>Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer >Sleep disorders in advanced cancer patients: prevalence and factors associated.
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Sleep disorders in advanced cancer patients: prevalence and factors associated.

机译：晚期癌症患者的睡眠障碍：患病率和相关因素。

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GOALS OF WORK: Sleep disorders have been invariably reported in cancer population. However, the prevalence of this problem in advanced cancer patients has never been assessed. The aim of this study was to evaluate the frequency of sleep disturbances in terms of quantity and quality, and possible associated factors. PATIENTS AND METHODS: A consecutive sample of patients admitted to a pain relief and palliative care unit were surveyed. Patients with severe cognitive problems or who were too ill were excluded. Epidemiological and clinical data, including the performance status, habits, relevant symptoms, and drug use were recorded. Patients were asked to answer a small questionnaire regarding their sleep, and duration and characteristics (nocturnal and diurnal hours slept, falling asleep, awaking, getting back to sleep, early awaking, restoring sleep, nightmares, feeling depressed or anxious). The level of information about the illness was also assessed. MAIN RESULTS: Among the causes of admission, pain control was the main indication (about 58%). Of 123 patients surveyed, 30% slept less than 5 h. Women significantly slept more hours than men (p=0.042). Anxiety (p=0.045), falling asleep (p=0.003), awaking (p=0.035), early awaking (p=0.001), getting beck to sleep (p=0.021), and nightmares (p=0.034), were significantly associated with less hours slept. This relationship was highly significant for less restoring sleep, fatigue, and drowsiness ( p<0.0005). No differences were found for age (p=0.294), primary tumor (p=0.225), level of information ( p=0.529), Karnofsky status (p=0.539), depression (p= 0.095), confusion (p=0.074), possible causes of awaking (p= 0.881), use of opioids (p= 0.798), use of hypnotics (p= 0.197), other morbidities ( p=0.460), or use of alcohol or coffee (p= 0.141). Patients admitted for pain control and/or those receiving opioids more frequently had drowsiness (p=0.01) Patients with lower Karnofsky scores had more drowsiness and diurnal hours slept (p=0.01). Anxiety created more difficulties in falling asleep, produced a less restoring sleep, and nightmares. Depression was associated with early awaking, nonrestorative sleep, fatigue, and nightmares. Confusion was associated with fatigue and nightmares. CONCLUSION: Sleep problems appear to be a significant issue for advanced cancer patients. Attention to sleep disturbance needs to be incorporated into the routine practice in palliative care evaluation.
机译：工作目标：癌症人群中始终有睡眠障碍的报道。然而，从未评估该问题在晚期癌症患者中的普遍性。这项研究的目的是根据数量和质量以及可能的相关因素来评估睡眠障碍的发生频率。病人和方法：对入院止痛和姑息治疗单位的患者的连续样本进行了调查。患有严重认知问题或病情过重的患者被排除在外。记录流行病学和临床数据，包括表现状态，习惯，相关症状和药物使用情况。要求患者回答有关其睡眠以及睡眠时间和特征（夜间和昼夜睡眠，入睡，醒来，重新入睡，早醒，恢复睡眠，噩梦，沮丧或焦虑）的小型问卷。还评估了有关疾病的信息水平。主要结果：入院原因中，止痛是主要适应症（约58％）。在接受调查的123位患者中，有30％的患者睡眠时间少于5小时。女性的睡眠时间明显多于男性（p = 0.042）。焦虑（p = 0.045），入睡（p = 0.003），醒来（p = 0.035），早醒（p = 0.001），贝克入睡（p = 0.021）和噩梦（p = 0.034）明显与更少的睡眠时间相关。这种关系对于减少睡眠，疲劳和嗜睡的恢复具有高度意义（p <0.0005）。没有发现年龄（p = 0.294），原发肿瘤（p = 0.225），信息水平（p = 0.529），卡诺夫斯基状态（p = 0.539），抑郁症（p = 0.095），精神错乱（p = 0.074）的差异。 ，可能的苏醒原因（p = 0.881），使用阿片类药物（p = 0.798），使用催眠药（p = 0.197），其他发病率（p = 0.460）或使用酒精或咖啡（p = 0.141）。接受止痛治疗的患者和/或接受阿片类药物治疗较多的患者出现嗜睡（p = 0.01）。Karnofsky评分较低的患者有嗜睡和昼夜睡眠（p = 0.01）。焦虑给入睡带来了更多困难，使睡眠恢复减少，并产生了噩梦。抑郁与早醒，非恢复性睡眠，疲劳和恶梦有关。混乱与疲劳和噩梦有关。结论：睡眠问题似乎是晚期癌症患者的重要问题。在姑息治疗评估中，应将对睡眠障碍的关注纳入常规实践。

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