Efficacy and safety of olanzapine for the prophylaxis of chemotherapy-induced nausea and vomiting (CINV) as reported in phase I and II studies: a systematic review

Chow Ronald; Chiu Leonard; Navari Rudolph; Passik Steven; Chiu Nicholas; Popovic Marko; Lam Henry; Pasetka Mark; Chow Edward; DeAngelis Carlo

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Efficacy and safety of olanzapine for the prophylaxis of chemotherapy-induced nausea and vomiting (CINV) as reported in phase I and II studies: a systematic review

机译：一期和二期研究报告的奥氮平预防化疗引起的恶心和呕吐（CINV）的功效和安全性：系统综述

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Olanzapine is an atypical antipsychotic drug that inhibits serotonergic, dopaminergic, alpha-1 adrenergic, histaminic, and muscarinic receptors. Several phase I and II trials have been published documenting the use of olanzapine in controlling chemotherapy-induced nausea and vomiting (CINV). This review aims to summarize all phase I and II trials that reported on olanzapine for the prophylaxis of CINV.

机译：奥氮平是一种非典型的抗精神病药，可抑制血清素，多巴胺，α-1肾上腺素，组织蛋白和毒蕈碱受体。已经发表了一些I和II期试验，记录了奥氮平在控制化疗引起的恶心和呕吐（CINV）中的用途。本文旨在总结奥氮平预防CINV的所有I期和II期试验。

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《Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer》 |2016年第2期|共8页
作者
Chow Ronald; Chiu Leonard; Navari Rudolph; Passik Steven; Chiu Nicholas; Popovic Marko; Lam Henry; Pasetka Mark; Chow Edward; DeAngelis Carlo;
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正文语种 eng
中图分类护理学;
关键词
Olanzapine; Chemotherapy-induced nausea and vomiting; Prophylaxis; Efficacy; Safety;

机译：奥氮平;化学疗法引起的恶心和呕吐;预防;功效;安全性;

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1. Efficacy and safety of olanzapine for the prophylaxis of chemotherapy-induced nausea and vomiting (CINV) as reported in phase I and II studies: a systematic review [J] . Chow Ronald, Chiu Leonard, Navari Rudolph, Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer . 2016,第2期

机译：一期和二期研究报告的奥氮平预防化疗引起的恶心和呕吐（CINV）的功效和安全性：系统综述
2. Efficacy and safety of palonosetron for the prophylaxis of chemotherapy-induced nausea and vomiting (CINV): a systematic review and meta-analysis of randomized controlled trials. [J] . Marko Popovic, David G Warr, Carlo Deangelis, Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer . 2014,第6期

机译：帕洛诺司琼预防化疗引起的恶心和呕吐（CINV）的功效和安全性：随机对照试验的系统评价和荟萃分析。
3. A phase III open-label study to assess safety and efficacy of palonosetron for preventing chemotherapy-induced nausea and vomiting (CINV) in repeated cycles of emetogenic chemotherapy [J] . Kenjiro Aogi, Hiroshi Sakai, Hirohisa Yoshizawa, Supportive Care in Cancer . 2012,第7期

机译：III期开放标签研究，用于评估帕洛诺司琼在致癌化学反应重复周期中预防化学疗法引起的恶心和呕吐（CINV）的安全性和有效性
4. Using the 5W+1H Model in Reporting Systematic Literature Review: A Case Study on Software Testing for Cloud Computing [C] . Jia Changjiang, Yu Yuen Tak International Conference on Quality Software . 2013

机译：在报告系统文献回顾中使用5W + 1H模型：以云计算软件测试为例
5. Explorations of the use of Olanzapine for Management of Chemotherapy-induced Nausea and Vomiting in Children. [D] . Flank, Jacqueline. 2015

机译：探索使用奥氮平治疗儿童化疗引起的恶心和呕吐。
6. A randomized phase III study evaluating the efficacy of single-dose NEPA a fixed antiemetic combination of netupitant and palonosetron versus an aprepitant regimen for prevention of chemotherapy-induced nausea and vomiting (CINV) in patients receiving highly emetogenic chemotherapy (HEC) [O] . L Zhang, S Lu, J Feng, -1

机译：一项III期随机研究评估单剂量NEPAnetupitant和palonosetron的固定止吐药与预防性方案在接受高促发性化疗（HEC）的患者中预防化疗引起的恶心和呕吐（CINV）的疗效
7. Pooled analysis of phase III clinical studies of palonosetron versus ondansetron, dolasetron, and granisetron in the prevention of chemotherapy-induced nausea and vomiting (CINV) [O] . Lee Schwartzberg, Sally Y. Barbour, Gary R. Morrow, 2013

机译：帕洛诺司琼与恩丹西酮，多拉西琼和格拉司琼在预防化学疗法诱发的恶心和呕吐（CINV）的III期临床研究中的汇总分析

Efficacy and safety of olanzapine for the prophylaxis of chemotherapy-induced nausea and vomiting (CINV) as reported in phase I and II studies: a systematic review

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