Atypical phenotypes in classical hodgkin lymphoma

WeissL.M.

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Atypical phenotypes in classical hodgkin lymphoma

机译：经典霍奇金淋巴瘤的非典型表型

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Classical Hodgkin lymphoma has a characteristic immunophenotype in most cases, with expression of CD30, CD15, and PAX-5, and absence of CD45 and T-lineage markers. However, in a significant subset of cases, atypical staining patterns may be seen for one or more antigens, particularly negative staining for CD15 or staining for one or more B-lineage markers, such as CD20, CD79a, OCT-2, or BOB.1. The greatest pitfall is in the misinterpretation of other cells, such as immunoblasts or histiocytes, as Hodgkin cells.

机译：在大多数情况下，经典霍奇金淋巴瘤具有特征性的免疫表型，具有CD30，CD15和PAX-5的表达，而没有CD45和T谱系标记。但是，在相当多的情况下，可能会看到一种或多种抗原的非典型染色模式，特别是CD15呈阴性染色或一种或多种B谱系标记（例如CD20，CD79a，OCT-2或BOB）染色。 1。最大的陷阱在于将其他细胞（例如免疫母细胞或组织细胞）误解为霍奇金细胞。

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《Surgical pathology clinics》 |2013年第4期|共14页
作者
WeissL.M.;
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正文语种 eng
中图分类病理学;
关键词
BOB.1; CD15; CD20; CD30; CD45; CD79a; Immunohistochemistry; OCT-2; PAX-5;

机译：BOB.1;CD15;CD20;CD30;CD45;CD79a;免疫组化;OCT-2;PAX-5;

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1. Refractory Classical Hodgkin Lymphoma Presenting with Atypical Cutaneous Involvement and Diagnosis of ZZ Phenotype Alpha-1 Antitrypsin Deficiency [J] . MohamadKhawandanah, TeresaKraus, MohamadCherry Case Reports in Hematology . 2014,第1期

机译：难治性经典霍奇金淋巴瘤伴非典型皮肤参与和ZZ表型α-1抗胰蛋白酶缺乏症的诊断
2. Peripheral T-cell lymphoma NOS arising in patients with classical Hodgkin lymphoma of cytotoxic phenotype [J] . Huettl Katrin S., Staiger Annette M., Stehle Alexander, Leukemia and lymphoma . 2019,第13a14期

机译：患有细胞毒性表型典型霍奇金淋巴瘤患者的外周T细胞淋巴瘤。
3. Restoring the Lost B-Cell Phenotype Renders Classical Hodgkin's Lymphoma Susceptible to B-Cell-Targeting Therapies [J] . Neuendorff Nina Rosa, Du Jing, Yu Yong, Blood: The Journal of the American Society of Hematology . 2016,第22期

机译：恢复丢失的B细胞表型会使经典霍奇金淋巴瘤易受B细胞靶向疗法的影响
4. Robust Diagnosis of Non-Hodgkin Lymphoma Phenotypes Validated on Gene Expression Data fromDifferent Laboratories [C] . Gyan Bhanot, Gabriela Alex International Workshop on Bioinformatics and Systems Biology . 2005

机译：从Drifferent Laboratories的基因表达数据验证的非霍奇金淋巴瘤表型的鲁棒诊断
5. Risk of Depressive or Anxiety Disorders in Commercially Insured Patients with Non-Hodgkin Lymphoma (NHL) in the US: A Retrospective Analysis [D] . Sun, Lucille 2017

机译：美国非霍奇金淋巴瘤（NHL）商业保险患者发生抑郁或焦虑症的风险：回顾性分析
6. Refractory Classical Hodgkin Lymphoma Presenting with Atypical Cutaneous Involvement and Diagnosis of ZZ Phenotype Alpha-1 Antitrypsin Deficiency [O] . Mohamad Khawandanah, Teresa Kraus, Mohamad Cherry 2014

机译：难治性经典霍奇金淋巴瘤伴非典型皮肤参与和ZZ表型α-1抗胰蛋白酶缺乏症的诊断
7. Classical nodular sclerosis Hodgkin lymphoma presenting with atypical cardiac involvement [O] . Georgiana Butura, Ion Antohe, Catalin Danaila, 2016

机译：典型的结节硬化霍奇金淋巴瘤呈现出非典型心脏受累

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Atypical phenotypes in classical hodgkin lymphoma

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