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Maternal Floor Infarction and Massive Perivillous Fibrin Deposition.

机译:产妇底板梗塞和大量周周性纤维蛋白沉积。

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摘要

Maternal floor infarction (MFI) and massive perivillous fibrin deposition (MPVFD) are pathologically overlapping placental disorders with characteristic gross and shared light microscopic features of excessive perivillous deposition of fibrinoid material. Although rare, they are associated with high rates of fetal growth restriction, perinatal morbidity and mortality, and risks of recurrence with fetal death. The cause of the extensive fibrinoid deposition is unknown, but evidence supports involvement of maternal alloimmune or autoimmune mechanisms. This article presents an updated discussion of features, placental histopathologic differential diagnosis, possible causes, clinical correlates, and adverse outcomes of the MFI/MPVFD spectrum.
机译:孕产妇底梗死(MFI)和大量周炎性纤维蛋白沉积(MPVFD)是病理重叠的胎盘疾病,其特征是粗大的和共享的光镜特征是纤维蛋白样物质的过度周炎性沉积。尽管罕见,但它们与胎儿生长受限率高,围产期发病率和死亡率高以及胎儿死亡复发的风险有关。广泛的纤维蛋白样沉积的原因尚不清楚,但证据支持母源同种免疫或自身免疫机制的参与。本文介绍了MFI / MPVFD频谱的特征,胎盘组织病理学鉴别诊断,可能的原因,临床相关性和不良后果的最新讨论。

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