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Endocrine Pathology: Treading Water in a Shark Tank ofUncertain Malignant Potential

机译:内分泌病理学:在恶性潜能不确定的鲨鱼缸中踩水

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摘要

A wonderful thing about endocrine-related diseases is that most of them make sense. Unlike the complicated rmolalities of the Loop of Henle or the mapping of the complex and vaguely specific geography of the brain, we can logically contemplate the mechanism of action of central to end-organ feedback of hormone regulation. If the body physiologically requires more calcium, calcium sensors tell the parathyroid to facilitate increased calcium absorption and secretion. To maintain homeostasis in body temperature and metabolism, thyrotropin-releasing hormone does a well-rehearsed dance with thyroid-stimulating hormone (TSH; or thyrotropin), which, in turn, greets the transmembrane TSH receptor in the thyroid to facilitate iodine uptake via the sodium iodide symporter and the production of thyroid hormone by thyrocytes.
机译:内分泌相关疾病的一个奇妙之处在于它们中的大多数都有意义。与Henle Loop复杂的摩尔浓度或大脑复杂复杂的特定地理位置的映射不同,我们可以从逻辑上考虑激素对中枢至终末器官反馈的作用机制。如果人体在生理上需要更多的钙,则钙传感器会告诉甲状旁腺,以促进钙的吸收和分泌。为了维持体内温度和代谢的稳态,促甲状腺激素释放激素与促甲状腺激素(TSH;或促甲状腺激素)进行了充分的排练,这反过来又迎合了甲状腺中的跨膜TSH受体,从而促进了碘的吸收。碘化钠同向转运蛋白和甲状腺细胞产生甲状腺激素。

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