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首页> 外文期刊>PACE: Pacing and clinical electrophysiology >Atrial overdriving is beneficial in patients with atrial arrhythmias: first results of the PROVE Study.
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Atrial overdriving is beneficial in patients with atrial arrhythmias: first results of the PROVE Study.

机译：房速过快对房性心律不齐的患者有益：PROVE研究的第一项结果。

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摘要

The AF Prevention by Overdriving (PROVE) trial is an ongoing prospective study of the effectiveness of atrial overdrive pacing combined with an Automatic Rest Rate function in the prevention of atrial arrhythmias. All patients who have received a Talent DR 213 pacemaker are eligible for enrollment into the study. After a 1-month monitoring period, the patients are divided into two groups. Group I includes patients with > or = 2 appropriate mode-switch (MS) episodes, or 1 MS episode of > or = 10 minutes, and/or > 300 atrial runs of > 5 beats/month. Group II includes all other patients. The number and duration of atrial arrhythmias are measured the pacemaker's Automatic Interpretation and Data Analysis software (AIDA). Patients' quality-of-life is measured by a validated functional status questionnaire. After having been grouped, the patients are randomly assigned, in a crossover design, to standard DDDR or overdrive pacing + Rest Rate, each programmed for a 3-month period. Preliminary results in 78 patients show a 34% reduction in the mean number of MS, and a mean 48% shortening of the overall duration of the episodes by overdrive pacing + Rest Rate, achieved by a mean 84% prevalence of atrial pacing. Overdrive pacing + Rest Rate was well tolerated and associated with a slight improvement in quality-of-life.
机译：AF预防超速驾驶（PROVE）试验是一项正在进行的前瞻性研究，涉及心房超速起搏和自动静息率功能在预防心律失常中的有效性。所有已接受Talent DR 213起搏器的患者都有资格参加研究。经过1个月的监测期后，将患者分为两组。第一组包括具有>或= 2适当模式转换（MS）发作，或1 MS发作>或= 10分钟和/或> 300次心房搏动≥5次/月的患者。第二组包括所有其他患者。心律失常的数量和持续时间由起搏器的自动解释和数据分析软件（AIDA）进行测量。患者的生活质量通过有效的功能状况调查表进行衡量。分组后，按照交叉设计将患者随机分配到标准DDDR或超速起搏+静息率，每个患者均编程3个月。 78名患者的初步结果显示，平均起搏频率+静息率可将平均MS数减少34％，将总体发作持续时间平均缩短48％，而平均心房起搏率则可达到84％。超速起搏+静息率的耐受性良好，生活质量略有改善。

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