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首页> 外文期刊>PACE: Pacing and clinical electrophysiology >An increase in plasma atrial natriuretic peptide concentration during exercise predicts a successful cardioversion and maintenance of sinus rhythm in patients with chronic atrial fibrillation.
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An increase in plasma atrial natriuretic peptide concentration during exercise predicts a successful cardioversion and maintenance of sinus rhythm in patients with chronic atrial fibrillation.

机译：运动过程中血浆心钠素浓度的增加预示着慢性心房颤动患者成功进行心脏复律并维持窦性心律。

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摘要

The aim of this study was to determine the value of an increase in plasma atrial natriuretic peptide (ANP) concentrations during submaximal exercise as a predictor of return of sinus rhythm (SR), and of its maintenance over a period of 6 months after cardioversion (CV) of chronic atrial fibrillation (AF). The study group included 42 patients with AF (mean duration 7 +/- 7 months) and a controlled ventricular rate. They underwent submaximal exercise testing 24 hours before CV. Blood samples were collected at rest and at peak of exercise for measurement of plasma ANP concentrations. Thirty-five of 42 patients were successfully cardioverted to SR. At 6 months, 23 patients remained in SR, while 12 had recurrence of AF. The plasma ANP concentrations before CV increased insignificantly during exercise in patients with unsuccessful CV or with recurrence of AF (60.8 +/- 17.3 pg/mL to 64 +/- 13.5 pg/mL, NS). The mean increase in plasma ANP concentration during exercise was significantly greater in the 23 patients who remained in SR than in the 19 patients unsuccessfully cardioverted or with recurrence of AF (17.5 +/- 7.6 pg/mL vs 5.8 +/- 4.5 pg/mL, P < 0.01). In multivariate logistic regression analysis, an increase in ANP plasma concentration was independently associated with successful CV and maintenance of SR up to 6 months of observation. In patients with chronic AF an exercise-induced increase in ANP concentration predicts successful CV and maintenance of SR.
机译：这项研究的目的是确定次最大运动过程中血浆心钠素浓度（ANP）升高的价值，作为窦性心律（SR）回归以及心律复律后6个月内维持的预测值（慢性心房纤颤（CV）。研究组包括42例房颤（平均病程7 +/- 7个月），心室率受控。他们在简历前24小时进行了次最大运动测试。在静止和运动高峰时采集血样以测量血浆ANP浓度。 42例患者中有35例成功转为SR。在6个月时，有23例患者保留SR，而12例复发了AF。 CV失败或AF复发的患者，在运动过程中血浆ANP浓度在运动过程中微不足道增加（60.8 +/- 17.3 pg / mL至64 +/- 13.5 pg / mL，NS）。留在SR的23例患者在运动过程中血浆ANP浓度的平均升高明显高于未成功心脏复律或AF复发的19例患者（17.5 +/- 7.6 pg / mL vs 5.8 +/- 4.5 pg / mL ，P <0.01）。在多因素logistic回归分析中，ANP血浆浓度的增加与成功的CV和长达6个月观察到的SR的维持独立相关。在患有慢性AF的患者中，运动引起的ANP浓度增加预示着成功的心血管和SR维持。

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