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首页> 外文期刊>PACE: Pacing and clinical electrophysiology >Tissue oximetry for the diagnosis of neurally mediated syncope.
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Tissue oximetry for the diagnosis of neurally mediated syncope.

机译：组织血氧饱和度用于神经介导晕厥的诊断。

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摘要

This study examined the potential clinical contribution of noninvasive brain and skeletal muscle oximetry as a diagnostic aid in neurally mediated syncope. Tilt table testing was performed in 15 patients with a history of syncope and 9 healthy volunteers. Spatially resolved reflectance near-infrared spectroscopy was used to examine regional oxyhemoglobin saturation in the frontal cerebral cortex and pectoral muscle. During upright tilt, syncope occurred in four patients. Each episode was associated with bradycardia, hypotension, and brain oxygen desaturation of > 20% from the supine reference baseline, while the largest desaturation in nonsyncopal patients was 13%. In two syncopal patients, a sudden increase in pectoral oxygen saturation preceded cerebral oxygen desaturation and unconsciousness, suggesting a sudden loss of peripheral sympathetic tone. Simultaneous desaturation in both tissues in the other two patients appeared to be in response to a diminished cardiac output. The muscle and brain oxygen saturation ratio increased by 75% with apparent sympathetic dysfunction, but never changed by > 25% in the other patients, and varied by < 15% in the volunteers. These results suggest that during tilt table testing, simultaneous assessment of brain and skeletal muscle oxygenation may provide a simple, objective aid for the identification of contributory sympathetic dysfunction.
机译：这项研究检查了无创性大脑和骨骼肌血氧饱和度测定作为神经介导晕厥的诊断辅助手段的潜在临床贡献。在15名有晕厥病史的患者和9名健康志愿者中进行了倾斜表测试。使用空间分辨反射近红外光谱法检查额叶大脑皮层和胸肌中的氧合血红蛋白饱和度。在直立倾斜期间，四名患者发生晕厥。每次发作均与心动过缓，低血压和从仰卧参考基线起> 20％的脑氧饱和度相关，而非晕厥患者中最大的饱和度降低为13％。在两名晕厥患者中，胸腔血氧饱和度突然升高先于脑氧饱和度下降和意识丧失，这表明周围交感神经突然消失。在另外两名患者中，两个组织中的同时去饱和似乎是对心输出量减少的反应。有明显的交感神经功能障碍时，肌肉和大脑的氧饱和度比率增加了75％，但其他患者中从未改变> 25％，而自愿者则变化了<15％。这些结果表明，在倾斜台测试过程中，同时评估大脑和骨骼肌的氧合可能为识别交感神经功能障碍提供简单，客观的帮助。

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