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首页> 外文期刊>PACE: Pacing and clinical electrophysiology >Magnesium adjunctive therapy in atrial arrhythmias
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Magnesium adjunctive therapy in atrial arrhythmias

机译:镁辅助治疗心律失常

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摘要

Magnesium (Mg) is an important intracellular ion with cardiac metabolism and electrophysiologic properties. A large percentage of patients with arrhythmias have an intracellular Mg deficiency, which is out of line with serum Mg concentrations, and this may explain the rationale for Mg's benefits as an atrial antiarrhythmic agent. A current limitation of antiarrhythmic therapy is that the potential for cardiac risk offsets some of the benefits of therapy. Mg enhances the balance of benefits to harms by enhancing atrial antiarrhythmic efficacy and reducing antiarrhythmic proarrhythmia potential as well as providing direct antiarrhythmic efficacy when used as monotherapy in patients undergoing cardiothoracic surgery.
机译:镁(Mg)是一种重要的细胞内离子,具有心脏代谢和电生理特性。心律失常的很大一部分患者存在细胞内镁缺乏症,这与血清Mg浓度不符,这可能解释了Mg作为房性抗心律不齐药物的益处。抗心律失常治疗的当前局限性是心脏疾病的潜在风险抵消了治疗的某些益处。镁可提高心房抗心律失常的疗效,降低抗心律失常的心律失常的可能性,并在接受心胸外科手术的患者作为单一疗法使用时,可提供直接的抗心律失常的功效,从而增强利弊之间的平衡。

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