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首页> 外文期刊>PACE: Pacing and clinical electrophysiology >Effects of an angiotensin II antagonist on reperfusion arrhythmias in dogs.
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Effects of an angiotensin II antagonist on reperfusion arrhythmias in dogs.

机译：血管紧张素II拮抗剂对犬再灌注心律失常的作用。

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摘要

Losartan, an angiotensin II receptor antagonist with no bradykinin potentiating property, provides the opportunity to study the consequences of blocking angiotensin II. The objective of this study was to evaluate the antiarrhythmic responses of reperfusion arrhythmia to losartan in dogs. The effects of losartan on ventricular tachyarrhythmias induced during occlusion and reperfusion of the left anterior descending coronary artery were investigated in 30 dogs. The animals were randomized to receive either losartan (n = 15) or saline (n = 15). The VF inducing threshold was measured before occlusion and after reperfusion. Losartan (50 micrograms/kg per min) or saline was intravenously administered 5 minutes before occlusion and continued throughout the entire study period. The incidence of ventricular tachyarrhythmias during reperfusion was lower in the losartan group than in the control group (4/15 vs 6/15). There was no significant change in VF inducing threshold between the period before occlusion and during reperfusion in the losartan group [10.9 +/- 5.7 vs 11.1 +/- 5.7 mA, P = NS), whereas there was a significant decrease in the control group (15.5 +/- 4.4 vs 7.7 +/- 3.9 mA, P < 0.01). Blockade of the angiotensin II receptor has beneficial effects on reperfusion arrhythmias.
机译：Losartan是一种没有缓激肽增强作用的血管紧张素II受体拮抗剂，为研究阻断血管紧张素II的后果提供了机会。这项研究的目的是评估狗对氯沙坦的再灌注心律失常的抗心律失常反应。研究了氯沙坦对30只犬闭塞和再灌注左冠状动脉前降支期间诱发的室性快速性心律失常的作用。将动物随机接受氯沙坦（n = 15）或生理盐水（n = 15）。在闭塞前和再灌注后测量VF诱导阈值。在闭塞前5分钟静脉注射氯沙坦（50微克/千克每分钟）或生理盐水，并在整个研究期间持续进行。氯沙坦组再灌注期间室性心律失常的发生率低于对照组（4/15比6/15）。氯沙坦组在闭塞前至再灌注期间，VF诱导阈值无明显变化（10.9 +/- 5.7 vs 11.1 +/- 5.7 mA，P = NS），而对照组明显降低（15.5 +/- 4.4与7.7 +/- 3.9 mA，P <0.01）。血管紧张素Ⅱ受体的阻断对再灌注性心律不齐具有有益作用。

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