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首页> 外文期刊>PACE: Pacing and clinical electrophysiology >Relation between microvolt level T wave alternans and other potential noninvasive predictors of arrhythmic risk in the Marburg Cardiomyopathy Study.
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Relation between microvolt level T wave alternans and other potential noninvasive predictors of arrhythmic risk in the Marburg Cardiomyopathy Study.

机译:在马尔堡心肌病研究中,微伏级T波交替蛋白与其他可能的无创性心律失常风险预测因子之间的关系。

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The relation between microvolt level T wave alternans (TWA) and other noninvasive arrhythmia risk predictors was analyzed in 221 consecutive patients with idiopathic dilated cardiomyopathy (IDC) and sinus rhythm enrolled in the Marburg Cardiomyopathy Study between March 1996 and May 2000. TWA analysis was also performed in 110 healthy controls of similar age and sex. TWA during symptom-limited exercise was positive, negative and indeterminate in, respectively, 108 (49%), 65 (29%) and 48 (22%) patients with IDC versus, respectively, 5 (5%), 98 (89%) and 7 (6%) healthy controls (P < 0.05). Patients with IDC and positive TWA had a lower left ventricular (LV) ejection fraction (29 +/- 9% vs 34 +/- 10%, P < 0.05) and greater LV end-diastolic diameter (69 +/- 8 mm versus 64 +/- 6 mm, P < 0.05) than patients with negative TWA. Other variables, including age, gender, New York Heart Association functional class, presence of bundle branch block, arrhythmias on 24-hour ambulatory electrocardiogram, heart rate variability and baroreflex sensitivity, were not significantly different between patients with positive vs negative TWA. The prognostic significance of TWA in IDC with regard to arrhythmic events and total mortality will be determined by multivariate Cox analysis at the end of a 5-year follow-up in this ongoing study.
机译:在1996年3月至2000年5月间参加了马尔堡心肌病研究的221例特发性扩张型心肌病(IDC)和窦律的连续患者中,分析了微伏级T波交替蛋白(TWA)与其他非侵入性心律失常风险预测因子之间的关系。在110个年龄和性别相仿的健康对照中进行。症状受限运动期间的TWA在IDC患者中分别为108(49%),65(29%)和48(22%)IDC为阳性,阴性和不确定,而分别为5(5%),98(89%) )和7位(6%)健康对照(P <0.05)。 IDC和TWA阳性的患者左心室(LV)射血分数较低(29 +/- 9%vs 34 +/- 10%,P <0.05)和较大的LV舒张末期直径(69 +/- 8 mm比TWA阴性的患者高64 +/- 6 mm,P <0.05)。 TWA阳性与阴性的患者之间的其他变量,包括年龄,性别,纽约心脏协会功能等级,束支传导阻滞的存在,24小时动态心电图上的心律不齐,心率变异性和压力反射敏感性均无显着差异。在这项正在进行的研究的5年随访期结束时,将通过多变量Cox分析确定TWA在IDC中对心律失常事件和总死亡率的预后意义。

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