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首页> 外文期刊>PACE: Pacing and clinical electrophysiology >Prevalence and clinical course of the juveniles with Brugada-type ECG in Japanese population.
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Prevalence and clinical course of the juveniles with Brugada-type ECG in Japanese population.

机译：Brugada型心电图在日本人群中的患病率和临床过程。

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BACKGROUND: Although many studies on Brugada syndrome have been done, with many reports of genetic findings and clinical features, little evidence exists to support the role of this syndrome in sudden cardiac death in a juvenile population. We sought to determine the prevalence and clinical course in children exhibiting Brugada-type ECG in a community-based population. METHODS: Our study population comprised 21,944 subjects (11,282 boys and 10,662 girls) who underwent ECG during their first-year elementary school health examinations between 1992 and 2001 in Izumi City, Osaka. Brugada-type ECG was defined as demonstrating ST-segment elevation (coved or saddle-back type, J wave amplitude > or =0.2 mV) in the right precordial leads. We also divided Brugada-type ECGs into three types according to a consensus report. Type 1: coved ST-segment elevation displaying high J wave amplitude followed by a negative T wave; Type 2: high take-off and gradually descending ST-segment elevation (remaining > or =1 mm) followed by a positive or biphasic T wave; and Type 3: ST-segment elevation of <1 mm of both types. RESULTS: Four subjects showed Brugada-type ECG (0.02%) (2 boys and 2 girls). Only one subject, a girl, met Type 1 criteria (0.005%). No history of structural heart disease was documented in these four subjects. During 6.8 +/- 1.0 years of follow-up, no episode of unexpected sudden death, syncopal attack, and fatal arrhythmia occurred. CONCLUSIONS: The prevalence of Brugada-type ECG in a juvenile population was extremely low. To investigate when the typical Brugada-type ECG might be manifested, it could be necessary to check ECGs after adolescence.
机译：背景：尽管已经完成了许多关于Brugada综合征的研究，并且有许多关于遗传学发现和临床特征的报道，但很少有证据支持该综合征在青少年心源性猝死中的作用。我们试图确定在以社区为基础的人群中表现出Brugada型ECG的儿童的患病率和临床过程。方法：我们的研究人群包括21,944名受试者（11,282名男孩和10,662名女孩），他们在1992年至2001年于大阪府泉市进行的一年级小学健康检查中接受了心电图检查。 Brugada型心电图定义为在右心前导联中显示ST段抬高（弯曲或鞍背型，J波幅度>或= 0.2 mV）。根据共识报告，我们还将Brugada型ECG分为三类。类型1：弯曲的ST段高程显示出高J波幅值，然后是负T波;类型2：高起飞并逐渐降低ST段抬高（保持>或= 1 mm），然后是正向或两相T波;和类型3：两种类型的ST段标高均小于1毫米。结果：4名受试者表现出Brugada型心电图（0.02％）（2男2女）。只有一名受试者（女孩）符合1类标准（0.005％）。在这四个受试者中均未记录有结构性心脏病的病史。在6.8 +/- 1.0年的随访期间，未发生意外猝死，晕厥发作和致命性心律失常的发作。结论：青少年人群中Brugada型心电图的患病率极低。为了调查何时可能出现典型的Brugada型心电图，可能有必要在青春期后检查心电图。

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