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首页> 外文期刊>PACE: Pacing and clinical electrophysiology >Implantable cardioverter defibrillator therapy for prevention of sudden cardiac death in children in the Netherlands
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Implantable cardioverter defibrillator therapy for prevention of sudden cardiac death in children in the Netherlands

机译：植入式心脏复律除颤器疗法在荷兰预防儿童猝死

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Introduction: Implantable cardioverter defibrillator (ICD) therapy is increasingly used in children. The purpose of this multicenter study is to evaluate mid-term clinical outcome and to identify predictors for device discharge in pediatric ICD recipients. Methods and Results: From 1995 to 2006, 45 patients in The Netherlands under the age of 18 years received an ICD. Mean age at implantation was 10.8 ± 5.2 years. Primary prevention (N = 22) and secondary prevention (N = 23) were equally distributed. Underlying cardiac disorders were primary electrical disease (55%), cardiomyopathy (20%), and congenital heart disease (17%). The follow-up was 44 ± 32.9 months. Three patients (7%) died and one patient (2%) underwent heart transplantation. ICD-related complications occurred in eight patients (17%), seven of whom had lead-related complications. Fourteen patients (31%) received appropriate ICD shocks; 12 patients (27%) received inappropriate ICD shocks. Fifty-five percent of 22 ICD recipients under the age of 12 years received appropriate shocks, which was higher as compared with 9% of 23 older ICD recipients (P = 0.003). Although the incidence of appropriate shocks in the present study was larger in secondary prevention (9/23; 39%) as compared with primary prevention (5/22; 23%), this difference did not reach significance. Conclusions: In our population of patients, children <12 years of age had more appropriate shocks than patients 13-18 years. The complication rate is low, and is mainly lead related.
机译：简介：植入式心脏复律除颤器（ICD）治疗越来越多地应用于儿童。这项多中心研究的目的是评估中期临床结果，并确定小儿ICD接受者中器械放电的预测因素。方法和结果：从1995年到2006年，荷兰的45名18岁以下的患者接受了ICD。植入时的平均年龄为10.8±5.2岁。一级预防（N = 22）和二级预防（N = 23）分布均匀。潜在的心脏疾病包括原发性电疾病（55％），心肌病（20％）和先天性心脏病（17％）。随访44±32.9个月。 3例患者（7％）死亡，1例患者（2％）接受了心脏移植。 ICD相关并发症发生在8名患者中（17％），其中7名患有铅相关并发症。 14名患者（31％）接受了适当的ICD电击; 12例患者（27％）接受了不适当的ICD电击。在22岁以下的22名ICD接受者中，有55％受到了适当的电击，高于23名年龄较大的ICD接受者中的9％（P = 0.003）。尽管在本研究中，适当的电击发生率在二级预防（9/23; 39％）中比一级预防（5/22; 23％）要大，但这种差异没有显着性。结论：在我们的患者人群中，<13岁的儿童比13-18岁的儿童更适合遭受电击。并发症发生率低，主要与铅有关。

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