...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>PACE: Pacing and clinical electrophysiology >Are nonsustained ventricular tachycardias predictive of major arrhythmias in patients with dilated cardiomyopathy on optimal medical treatment?
【24h】

Are nonsustained ventricular tachycardias predictive of major arrhythmias in patients with dilated cardiomyopathy on optimal medical treatment?

机译：非持续性室性心动过速是否可以通过最佳药物治疗来预测扩张型心肌病患者的主要心律失常？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: To evaluate the role of nonsustained ventricular tachycardias (NSVT) for the prediction of major ventricular arrhythmias (MVA) in patients with idiopathic dilated cardiomyopathy (DCM) after optimization of medical treatment. METHODS AND RESULTS: Three hundred nineteen consecutive DCM patients were evaluated after adequate stabilization on optimal angiotensin-converting enzyme (ACE) inhibitor (88%) and beta-blocker (82%) therapy. Frequency, length, and rate of NSVT at 24-hour Holter monitoring were analyzed to assess their values in predicting MVA (unexpected sudden death, SVT, ventricular fibrillation, and appropriate implantable cardioverter defibrillator interventions). During follow-up (median 96 months, 1(st)-3(rd) interquartile range 52-130), MVA incidence was low, and not statistically different between patients with and without NSVT (3 and 2 per 100 patient-years, respectively, P = nonsignificant [NS] at log-rank analysis). At multivariable analysis, the number of NSVT was predictiveof MVA only if left ventricular ejection fraction (LVEF) was > 0.35 (two NSVT/day vs no NSVT/day: hazard ratio [HR] 5.3, 95% confidence interval [CI] 1.59-17.85 in LVEF > 0.35 vs HR 0.93, 95% CI 0.3-2.81 in LVEF < or = 0.35). Consequently, in patients with LVEF < or = 0.35, MVA incidence rates were similar regardless of NSVT (3.6 and 4.1 patient-years, respectively, in those with and without NSVT, P = NS), while in patients with LVEF > 0.35, MVA incidence (3.1 per 100 patient-years vs 0.9 per 100 patient-years, P = 0.003) was significantly higher when NSVT were present. CONCLUSIONS: After medical stabilization, NSVT did not increase the risk of MVA in patients with DCM and LVEF < or = 0.35. Conversely, the number and length of NSVT runs were significantly related to the occurrence of MVA in the patients with LVEF > 0.35.
机译：背景：评价非持续性室性心动过速（NSVT）在优化药物治疗后对特发性扩张型心肌病（DCM）患者的主要室性心律不齐（MVA）的预测作用。方法和结果：在最佳血管紧张素转换酶（ACE）抑制剂（88％）和β受体阻滞剂（82％）充分稳定后，对119例连续DCM患者进行了评估。分析了24小时动态心电图监测中NSVT的频率，长度和发生率，以评估其在预测MVA（意外死亡，SVT，心室纤颤和适当的植入式心脏复律除颤器干预措施）中的价值。在随访期间（中位96个月，四分位数的第1（st）-3（rd）区间为52-130），MVA发生率较低，有无NSVT的患者之间无统计学差异（每100患者年3和2，分别在对数秩分析中P =不重要[NS]。在多变量分析中，仅当左心室射血分数（LVEF）> 0.35时，NSVT的数目才可预测MVA（两次NSVT /天与无NSVT /天：危险比[HR] 5.3、95％置信区间[CI] 1.59- LVEF> 0.35时为17.85 vs HR 0.93，LVEF <或= 0.35时为95％CI 0.3-2.81）。因此，在LVEF <或= 0.35的患者中，无论NSVT为何，MVA的发生率相似（在有和没有NSVT的患者中分别为3.6和4.1患者-年，P = NS），而在LVEF> 0.35的患者中，MVA当存在NSVT时，发病率（每100个病人年3.1个vs.每100个病人年0.9个，P = 0.003）显着更高。结论：在药物稳定后，NSVT不会增加DCM和LVEF <或= 0.35的患者发生MVA的风险。相反，在LVEF> 0.35的患者中，NSVT的次数和长度与MVA的发生显着相关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号