...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>PACE: Pacing and clinical electrophysiology >Associations between electrocardiographic interval durations and coronary artery calcium scores: the Diabetes Heart Study.
【24h】

Associations between electrocardiographic interval durations and coronary artery calcium scores: the Diabetes Heart Study.

机译：心电图间隔时间与冠状动脉钙评分之间的关​​联：《糖尿病心脏研究》。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: The mechanisms underlying the associations between QT interval duration and risk of cardiovascular disease (CVD) remain unclear. It has been assumed that these associations are driven by abnormal myocardial repolarization. We examined the relationship between coronary artery disease, measured by coronary artery calcified plaque (CAC), and the duration of QRS, JT, and QT intervals, among predominantly type two diabetic participants. METHODS: The study sample included 1,123 subjects from the Diabetes Heart Study, of whom 85% had type 2 diabetes. Correlations between electrocardiogram interval durations and log-transformed coronary artery calcified (CAC) were assessed in univariate and sequential multivariable generalized estimating equation models adjusted for familial correlations, heart rate, age, race, gender, diabetes status, hypertension status, Body Mass Index (BMI), smoking status, systolic blood pressure, Low Density Lipoprotein (LDL) cholesterol, QT-prolonging medications, and use ofexogenous estrogen. RESULTS: QT interval duration significantly correlated with the extent of CAC in univariate (r = 0.09, P = 0.01) and multivariable models (r = 0.08, P = 0.01). We observed strong correlations between the QRS duration and CAC in univariate (r = 0.23, P < 0.0001) and adjusted models (r = 0.10, P = 0.01). In contrast, the JT interval was not associated with CAC. A strong correlation existed between the QRS interval and CAC in men (QRS: r = 0.24, P < or = 0.0001) and diabetics (QRS: r = 0.25, P < or 0.0001) but was absent in women and nondiabetics. These relationships were not modified by CVD, race, or presence of bundle branch block. CONCLUSION: QT duration correlates with the amount of CAC in a predominantly diabetic population. The association between QT duration and CAC is driven by QRS and not JT interval duration.
机译：背景：QT间隔持续时间和心血管疾病（CVD）风险之间的关联机制尚不清楚。已经假定这些关联是由异常的心肌复极化驱动的。我们检查了主要由两名糖尿病患者组成的冠状动脉钙化斑（CAC）测量的冠状动脉疾病与QRS，JT和QT间隔的持续时间之间的关系。方法：该研究样本包括来自糖尿病心脏研究的1,123名受试者，其中85％患有2型糖尿病。心电图间隔时间与对数转化的冠状动脉钙化（CAC）之间的相关性在单变量和顺序多变量广义估计方程模型中进行了评估，这些方程模型针对家族相关性，心率，年龄，种族，性别，糖尿病，高血压状况，体重指数（体重指数（BMI），吸烟状况，收缩压，低密度脂蛋白（LDL）胆固醇，延长QT的药物和使用外源性雌激素。结果：在单变量（r = 0.09，P = 0.01）和多变量模型（r = 0.08，P = 0.01）中，QT间期持续时间与CAC的程度显着相关。我们在单变量（r = 0.23，P <0.0001）和调整后的模型（r = 0.10，P = 0.01）中观察到QRS持续时间与CAC之间有很强的相关性。相反，JT间隔与CAC不相关。男性（QRS：r = 0.24，P <或= 0.0001）和糖尿病患者（QRS：r = 0.25，P <或0.0001）的QRS间隔与CAC之间存在很强的相关性，而女性和非糖尿病患者则无此关系。 CVD，种族或束支传导阻滞的存在并未改变这些关系。结论：QT持续时间与主要为糖尿病人群的CAC量相关。 QT持续时间和CAC之间的关联由QRS驱动，而不由JT间隔持续时间驱动。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号