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首页> 外文期刊>PACE: Pacing and clinical electrophysiology >Adenosine induced ventricular fibrillation in Wolff-Parkinson-White syndrome.
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Adenosine induced ventricular fibrillation in Wolff-Parkinson-White syndrome.

机译:Wolff-Parkinson-White综合征中腺苷引起的心室纤颤。

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VF was observed in four patients (group A) with preexcited AF presenting to the emergency department who had been given 12 mg of adenosine. These patients were resuscitated and underwent electrophysiological study and catheter ablation of the accessory pathway (AP). In a control (group B) of five patients with manifest AP, sustained AF was induced by rapid atrial pacing during electrophysiological study and 12 mg of adenosine was administered. The ECG and electrophysiologic features in the two groups were compared. All patients had a single manifest AP. In group A, three patients had a left free-wall AP and one patient had a posteroseptal AP, while in the control group all had left free-wall APs. The antegrade AP effective refractory period (ERP) in groups A and B was 227 +/- 29 and 289 +/- 37 ms, respectively (P < 0.05). The atrial ERP was 210 +/- 17 versus 219 +/- 21 ms, respectively, in groups A and B (P > 0.05). The shortest R-R interval during AF in group A was 246 +/- 51 ms and 301 +/- 60 ms in group B (P value < 0.05). After adenosine, no patient in group B developed VF. Adenosine may cause VF when administered during preexcited AF. This phenomenon is seen in patients having APs with short refractory periods.
机译:在向急诊科就诊并给予了12毫克腺苷的四名预激性AF患者(A组)中观察到VF。对这些患者进行复苏,并对其辅助通路(AP)进行电生理研究和导管消融。在5名有明显AP的患者的对照组(B组)中,在电生理研究期间通过快速心房起搏诱导了持续性房颤,并给予了12 mg腺苷。比较两组的心电图和电生理特征。所有患者都有一个明显的AP。在A组中,三名患者具有左自由壁AP,而一名患者具有后壁AP,而在对照组中,所有患者均具有左自由壁AP。 A组和B组的顺行AP有效不应期(ERP)分别为227 +/- 29和289 +/- 37 ms(P <0.05)。 A组和B组的心房ERP为210 +/- 17 ms,而219 +/- 21 ms(P> 0.05)。 A组在房颤期间最短的R-R间隔为246 +/- 51 ms,B组为301 +/- 60 ms(P值<0.05)。腺苷注射后,B组中没有患者出现VF。在预激性AF期间使用腺苷可能会导致VF。这种现象在难治期短的AP患者中可见。

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