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首页> 外文期刊>PACE: Pacing and clinical electrophysiology >Safety aspects of deep sedation during catheter ablation of atrial fibrillation
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Safety aspects of deep sedation during catheter ablation of atrial fibrillation

机译：心房纤颤导管消融期间深层镇静的安全性方面

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Background: The combination of intravenous propofol and midazolam is frequently used to provide unconscious sedation during catheter ablation of atrial fibrillation (AF), but only a very few reports are available on the influence of prolonged propofol infusion on arterial blood gas, blood pressure, and anesthesia-associated complications during ablation of AF. The purpose of this study was to assess tolerance and safety of unconscious sedation with intravenous propofol and midazolam during catheter ablation of AF. Methods: A total of 316 consecutive patients (age 59 ± 10 years, 68% men) presenting to our center for catheter ablation of symptomatic AF were enrolled prospectively. A total number of 424 procedures were performed under unconscious sedation with propofol and midazolam. SaO 2, electrocardiogram, arterial blood pressure, and arterial blood gases were monitored throughout the procedure. Results: Mean procedure duration was 235 ± 48 minutes. Patients received 1.125 ± 684 mg propofol, 9.5 ± 3 midazolam, and 1.963 ± 813 mL NaCl infusion. Complications during the procedure were identified in eight patients (2.5%, one × coronary air embolization, one × myocardial infarction, four × pericardial effusion, two × pericardial tamponade). All eight patients were symptomatic (distress, report of pain); none of the complications was attributable to unconscious sedation itself. Conclusion: Unconscious sedation with propofol and midazolam in AF ablation procedures lasting 3-5 hours did not result in severe changes of vital parameters or serum electrolytes. Anesthesia-associated problems were not observed. Propofol and midazolam can be safely used during catheter ablation of AF.
机译：背景：静脉使用丙泊酚和咪达唑仑的组合经常在心房纤颤（AF）导管消融期间用于无意识镇静，但只有很少的报道涉及长期输注丙泊酚对动脉血气，血压和血压的影响。房颤消融过程中与麻醉有关的并发症。这项研究的目的是评估房颤导管消融期间静脉注射丙泊酚和咪达唑仑无意识镇静的耐受性和安全性。方法：前瞻性入选了316名连续性患者，这些患者就诊于我们的有症状房颤的导管消融治疗中心（年龄59±10岁，男性占68％）。在异丙酚和咪达唑仑的无意识镇静下，总共进行了424例手术。在整个过程中，监测SaO 2，心电图，动脉血压和动脉血气。结果：平均手术时间为235±48分钟。患者接受1.125±684 mg异丙酚，9.5±3咪达唑仑和1.963±813 mL NaCl输注。在此过程中发现了8例并发症（2.5％，1例冠状动脉栓塞，1例心肌梗死，4例心包积液，2例心包填塞）。所有八名患者均出现症状（痛苦，疼痛报告）;没有任何并发​​症归因于无意识的镇静作用。结论：持续3-5小时的房颤消融术中丙泊酚和咪达唑仑的无意识镇静不会导致生命参数或血清电解质的严重改变。没有观察到麻醉相关的问题。房颤消融术中可以安全地使用异丙酚和咪达唑仑。

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