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首页> 外文期刊>PACE: Pacing and clinical electrophysiology >Efficacy and safety of catheter ablation for long-standing persistent atrial fibrillation in women
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Efficacy and safety of catheter ablation for long-standing persistent atrial fibrillation in women

机译：导管消融治疗女性长期持续性心房颤动的疗效和安全性

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Objectives It is uncertain whether gender affects the outcomes of catheter ablation (CA) for atrial fibrillation (AF). The objective of the study is to evaluate the efficacy and safety of CA for long-standing persistent AF in women. Methods Between January 2010 and May 2011, 220 consecutive patients (73 females, 33.2%), with long-standing persistent AF who underwent CA were prospectively recruited. Gender-related differences in clinical presentation, periprocedural complications, and outcomes were compared. Results Women were less likely to have lone AF than men (27.4% vs 47.6%; P = 0.004). The incidence of rheumatic heart disease was higher in women (19.2% in women vs 1.4% in men; P < 0.001). Women had a lower initial ablation success rate than men (35.6% vs 57.1%; P = 0.003). Hematomas occurred more often in women (6.8% in women vs 0.7% in men; P = 0.027). A Cox regression analysis demonstrated total duration of AF (per month, hazard ratio [HR] 1.003, confidence interval [CI] 1.001-1.006; P = 0.006) and gender (HR 1.663, CI 1.114-2.485; P = 0.013) as the independent predictors for recurrence after the first CA. Conclusions Women and long AF duration were closely related to the recurrence of AF after the first ablation in patients with long-standing persistent AF. Women also had a higher risk of vascular complications.
机译：目的尚不确定性别是否会影响房颤（AF）导管消融（CA）的结果。这项研究的目的是评估CA对女性长期持续性AF的疗效和安全性。方法在2010年1月至2011年5月期间，前瞻性招募了220例接受CA的长期持续性房颤患者，其中女性73例，占33.2％。比较了临床表现，围手术期并发症和预后方面的性别相关差异。结果女性患孤独症的可能性比男性少（27.4％比47.6％; P = 0.004）。女性风湿性心脏病的发病率更高（女性为19.2％，男性为1.4％; P <0.001）。女性的初始消融成功率低于男性（35.6％对57.1％; P = 0.003）。女性的血肿发生率更高（女性为6.8％，男性为0.7％; P = 0.027）。 Cox回归分析显示总房颤持续时间（每月，危险比[HR] 1.003，置信区间[CI] 1.001-1.006; P = 0.006）和性别（HR 1.663，CI 1.114-2.485; P = 0.013）为首次CA后复发的独立预测因子。结论长期持续性房颤患者首次消融后妇女与房颤持续时间长与房颤复发密切相关。妇女也有较高的血管并发症风险。

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