Synthesis of Novel 5-Trifluoromethyl-2,4,7-Trisubstituted Pyrido[2,3-d]Pyrimidines

S.Ravikanth; G.Venkat Reddy; D.Maitraie; V.V.V.N.S.Rama Rao; P.Shanthan Rao; B.Narsaiah

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Synthesis of Novel 5-Trifluoromethyl-2,4,7-Trisubstituted Pyrido[2,3-d]Pyrimidines

机译：新型5-三氟甲基-2,4,7-三取代的吡啶并[2,3-d]嘧啶的合成

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摘要

Novel pyrido[2,3-d]pyrimidines (2,4) were synthesized by reacting 2-amino-3-cyano-4-trifluoromethyl-6-substituted pyridines (1) with Grignard reagent followed by condensation with anhydride/chloro-acetylchloride/aromatic aldehyde.

机译：通过使2-氨基-3-氰基-4-三氟甲基-6-取代的吡啶（1）与格利雅试剂反应，然后与酸酐/氯乙酰氯缩合，合成新型吡啶并[2,3-d]嘧啶（2,4） /芳香醛。

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《Synthetic Communications》 |2004年第24期|共7页
作者
S.Ravikanth; G.Venkat Reddy; D.Maitraie; V.V.V.N.S.Rama Rao; P.Shanthan Rao; B.Narsaiah;
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正文语种 eng
中图分类有机化学;
关键词
Pyridines; Grignard reagent; Anhydride; Chloro-acetylchloride; Pyridopyrimidines;

机译：吡啶;格利雅试剂;酸酐;氯乙酰氯;吡啶嘧啶;

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1. Synthesis of Novel 5-Trifluoromethyl-2,4,7-Trisubstituted Pyrido[2,3-d]Pyrimidines [J] . S.Ravikanth, G.Venkat Reddy, D.Maitraie, Synthetic Communications . 2004,第24期

机译：新型5-三氟甲基-2,4,7-三取代的吡啶并[2,3-d]嘧啶的合成
2. Synthesis of some novel 4-imino-3,5,7-trisubstituted pyrido[2,3-d]pyrimidine-2(1H)-thiones and their nucleosides as potential therapeutic agents [J] . Singh G., Mishra AK., Yadav AK. Phosphorus, Sulfur, and Silicon and the Related Elements . 2000,第0期

机译：一些新型的4-亚氨基-3,5,7-三取代吡啶并[2,3-d]嘧啶-2（1H）-硫酮及其核苷的合成作为潜在的治疗剂
3. Pyrimidinethione as a building block in heterocyclic synthesis: synthesis of pyrano[2,3-d]pyrimidine, chromeno[2,3-d]pyrimidine, pyrido[3 ',2 ':5,6]pyrano[2,3-b]pyridine, and pyrimido[5 ',4 ':5,6]pyrano[2,3-d]pyrimidine derivatives [J] . Reheim Mohamed Ahmed Mahmoud Abdel, Hafiz Ibrahim Saad Abdel, Elian Mohamed Ahmed Heterocyclic communications . 2016,第6期

机译：嘧啶硫酮作为杂环合成的基础：吡喃并[2,3-d]嘧啶，苯并[2,3-d]嘧啶，吡啶并[3'，2'：5,6]吡喃并[2,3-b]的合成吡啶和嘧啶基[5'，4'：5,6]吡喃并[2,3-d]嘧啶衍生物
4. Microwave-Assisted Synthesis of Pyrimidines and 1,2-Dihydro-N-Aryl(Alkyl)-4,6-Dimethyl Pyrimidines [C] . (missing) International symposium on green chemistry in China . 2002

机译：微波辅助合成嘧啶和1,2-二氢 - N-芳基（烷基）-4,6-二甲基嘧啶
5. Synthesis of substituted pyrrolo[2,3-d]pyrimidines as microtubule-binding agents and HSP90 inhibitors [D] . Lin, Lu 2013

机译：取代吡咯并[2,3-d]嘧啶类化合物作为微管结合剂和HSP90抑制剂的合成
6. 2-Amino-57-bis(4-fluorophenyl)-1′3′-dimethyl-78-dihydrospiropyrido23-dpyrimidine-6(5H)5′-pyrimidine-2′44′6′(3H1′H3′H5′H)-tetraone ethanol solvate [O] . Xiao-Tong Zhu, Ge Zhang, Ning Ma 2009

机译：2-氨基-57-双（4-氟苯基）-13-二甲基-78-二氢螺吡啶并23-d嘧啶-6（5H）5-嘧啶- 2446（3H1H3H5H）-四酮乙醇溶剂化物
7. Diversity oriented synthesis : substitution at C5 in unreactive pyrimidines by Claisen rearrangement and reactivity in nucleophilic substitution at C2 and C4 in pteridines and pyrido[2,3-d]pyrimidines [O] . Adcock, Jonathan Paul, Gibson, Colin, Huggan, Judith, 2011

机译：面向多样性的合成：通过克莱森重排在C5中的非反应性嘧啶中进行取代，并在蝶啶和吡啶并[2,3-d]嘧啶中的C2和C4进行亲核取代中的反应性

Synthesis of Novel 5-Trifluoromethyl-2,4,7-Trisubstituted Pyrido[2,3-d]Pyrimidines

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