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首页> 外文期刊>Biomaterials >Drug delivery from gold and titanium surfaces using self-assembled monolayers.
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Drug delivery from gold and titanium surfaces using self-assembled monolayers.

机译：使用自组装单层从金和钛表面递送药物。

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Currently available drug-eluting stents (DES) use polymers for coating and releasing drugs. Increasing evidence suggests that inflammatory and hypersensitive reactions are caused by such polymer coatings. This study focused on developing new techniques for delivering drugs directly from metal implant surfaces. Hydroxyl-terminated self-assembled monolayers (SAMs) were coated on Au and Ti surfaces. Therapeutic self-assembled monolayers (TSAMs) were prepared by chemically attaching the model drug, flufenamic acid, to SAM coated metal surfaces. Three different methods of esterification (acid chloride esterification, dry heat esterification, and direct esterification) were explored to attach flufenamic acid to SAMs. TSAMs were characterized using X-ray photoelectron spectroscopy, fluorescence microscopy, atomic force microscopy, and contact angle goniometry. These techniques collectively confirmed the attachment of drug onto SAM coated metal surfaces. In vitro drug release was investigated by immersing TSAMcoated metal specimens in tris-buffered saline (TBS) at 37 degrees C for 28 days. TBS was analyzed at 1, 3, 7, 14, 21, and 28 days for the amount of drug eluted using high performance liquid chromatography. Large data scatter was observed for the release profiles of TSAMs prepared by acid chloride esterification. TSAMs prepared by dry heat and direct esterification methods showed an initial burst release of the drug followed by a sustained slow release for up to 2 weeks. Thus, this study suggests the potential for using self-assembled monolayers as an alternate system for delivering drugs from coronary stents and other metal implants.
机译：当前可用的药物洗脱支架（DES）使用聚合物来涂覆和释放药物。越来越多的证据表明，炎症和过敏反应是由这种聚合物涂层引起的。这项研究的重点是开发直接从金属植入物表面直接递送药物的新技术。将羟基封端的自组装单分子层（SAMs）涂覆在Au和Ti表面上。通过将模型药物氟苯胺酸化学附着到SAM涂层的金属表面上，制备治疗性自组装单层（TSAM）。探索了三种不同的酯化方法（酰氯酯化，干热酯化和直接酯化），以使氟苯那酸附着到SAMs上。使用X射线光电子能谱，荧光显微镜，原子力显微镜和接触角测角法对TSAM进行了表征。这些技术共同证实了药物在SAM涂层金属表面上的附着。通过将TSAM涂层的金属标本在37摄氏度的Tris缓冲盐水（TBS）中浸泡28天来研究体外药物释放。使用高效液相色谱法在1、3、7、14、21和28天分析TBS的药物洗脱量。对于通过酰氯酯化制备的TSAM的释放曲线，观察到大量数据散布。通过干热和直接酯化方法制备的TSAMs表现出药物的初始突释，然后持续缓慢释放长达2周。因此，这项研究表明使用自组装单层膜作为从冠状动脉支架和其他金属植入物输送药物的替代系统的潜力。

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