• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Chemical and Pharmaceutical Bulletin >Preparation and evaluation of solid dispersion for nitrendipine-carbopol and nitrendipine-HPMCP systems using a twin screw extruder.
【24h】

Preparation and evaluation of solid dispersion for nitrendipine-carbopol and nitrendipine-HPMCP systems using a twin screw extruder.

机译：使用双螺杆挤出机制备和评价尼群地平-卡波姆和尼群地平-HPMCP系统的固体分散体。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In the present study, we prepared solid dispersions of the poorly water-soluble drug nitrendipine (NIT) using the twin screw extruder method with high-molecular-weight substances, hydroxypropylmethylcellulosephthalate (HPMCP) and Carbopol (CAR), as carriers. Powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) evaluation showed that solid dispersions can be formed when NIT-HPMCP and NIT-CAR mixtures are treated with the twin screw extruder method. Fourier Transformation IR Spectroscopy (FT-IR) obtained with NIT-HPMCP and NIT-CAR solid dispersions indicated the presence of hydrogen bonding between the drug and the carriers. NIT-CAR solid dispersions were found to give somewhat higher dissolution than crystalline NIT and physical mixtures, while the dissolution of NIT-HPMCP solid dispersions was markedly decreased compared with the crystalline NIT and physical mixtures. These findings indicated that CAR has a greater ability to improve the dissolution of NIT than HPMCP when a twin screw extruder was employed to prepare the solid dispersions. The twin screw extruder method can be used as a simple and effective method for the preparation of solid dispersions to improve the dissolution properties of poorly water-soluble drugs when choosing proper polymers as carriers.
机译：在本研究中，我们使用高分子量物质，羟丙基甲基纤维素邻苯二甲酸酯（HPMCP）和Carbopol（CAR）作为载体，使用双螺杆挤出机方法制备了水溶性差的药物硝苯地平（NIT）的固体分散体。粉末X射线衍射（PXRD）和差示扫描量热法（DSC）评估表明，使用双螺杆挤出机方法处理NIT-HPMCP和NIT-CAR混合物时，可以形成固体分散体。使用NIT-HPMCP和NIT-CAR固体分散体获得的傅立叶变换红外光谱（FT-IR）表明，药物与载体之间存在氢键。发现NIT-CAR固体分散体比结晶NIT和物理混合物具有更高的溶解度，而与结晶NIT和物理混合物相比，NIT-HPMCP固体分散体的溶解度明显降低。这些发现表明，当使用双螺杆挤出机制备固体分散体时，CAR具有比HPMCP更大的改善NIT溶解的能力。当选择合适的聚合物作为载体时，双螺杆挤出机方法可以用作制备固体分散体的简单有效的方法，以改善水溶性差的药物的溶解性能。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号