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首页> 外文期刊>Sleep medicine reviews >Neuropsychological functioning after CPAP treatment in obstructive sleep apnea: A meta-analysis
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Neuropsychological functioning after CPAP treatment in obstructive sleep apnea: A meta-analysis

机译：CPAP治疗阻塞性睡眠呼吸暂停后的神经心理学功能：一项荟萃分析

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The generally held clinical view is that treatment with continuous positive airway pressure (CPAP) improves cognition in patients with obstructive sleep apnea (OSA). However, the cognitive domains in which recovery is found differ between studies. A meta-analysis was conducted to quantify the effect of CPAP treatment in OSA on neuropsychological functioning. A literature search of studies published from January 1990 to July 2012 was performed. The inclusion criteria were: randomized controlled trial, diagnosis of OSA by poly(somno)graphy, apnea/hypopnea index, duration and compliance of CPAP treatment reported, use of one or more standardized neuropsychological tests. Mean weighted effect sizes of CPAP treatment for seven cognitive domains were calculated, including processing speed, attention, vigilance, working memory, memory, verbal fluency and visuoconstruction. Thirteen studies encompassing 554 OSA patients were included. A small, significant effect on attention was observed in favor of CPAP (d=0.19). For the other cognitive domains the effect sizes did not reach significance. Improvement on measures of sleepiness was modest (d=0.30-0.53) and comparable to prior research. In conclusion, this meta-analysis indicates that the effect of CPAP on cognition is small and limited to attention. Contrary to the general assumption, only slight improvement of neuropsychological functioning after CPAP treatment can be expected.
机译：通常认为，持续气道正压通气（CPAP）治疗可改善阻塞性睡眠呼吸暂停（OSA）患者的认知。但是，研究之间发现恢复的认知领域有所不同。进行了荟萃分析，以量化OSA中CPAP治疗对神经心理功能的影响。对1990年1月至2012年7月发表的研究进行了文献检索。纳入标准为：随机对照试验，经多导图检查诊断OSA，呼吸暂停/呼吸不足指数，报告的CPAP治疗持续时间和依从性，使用一种或多种标准化的神经心理学测试。计算了七个认知领域的CPAP治疗的平均加权效应大小，包括处理速度，注意力，警惕性，工作记忆，记忆，言语流畅性和视觉建构。包括554名OSA患者在内的13项研究被纳入。观察到有利于CPAP的对注意力的微小显着影响（d = 0.19）。对于其他认知领域，效果大小没有达到显着性。嗜睡程度的改善是适度的（d = 0.30-0.53），与先前的研究相当。总而言之，这项荟萃分析表明，CPAP对认知的影响很小，并且仅限于关注。与一般的假设相反，CPAP治疗后神经心理功能只有轻微改善。

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