...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Chemical and Pharmaceutical Bulletin >Minor Withanolides from Physalis philadelphica: Structures, Quinone Reductase Induction Activities, and Liquid Chromatography (LC)-MS-MS Investigation as Artifacts
【24h】

Minor Withanolides from Physalis philadelphica: Structures, Quinone Reductase Induction Activities, and Liquid Chromatography (LC)-MS-MS Investigation as Artifacts

机译：酸浆中的小Withanolides：结构，醌还原酶诱导活性和液相色谱（LC）-MS-MS研究作为伪像

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

As a result of a bioactivity-guided search for novel, plant-derived cancer chemopreventive agents, ixocarpalactone A (5) was isolated previously as a potent quinone reductase inducer from the leaves and stems of Physalis philadelphica. In the present study, this promising lead compound was reisolated in gram quantities for in vivo biological testing. During the course of this work, four additional minor new withanolides were also obtained and characterized, namely, 2,3-dihydro-3β-methoxyixocarpalactone A(1), 2,3-dihydro-3β-methoxyixocarpalactone B(2), 2,3-dihydroixocarpalactone B(3), and 4β,7β,20R-trihydroxy-1-oxowitha-2,5-dien-22,26-olide (4). However, compounds 1 and 2 were determined using liquid chromatography (LC)-MS-MS to be artifacts generated during the extraction and isolation procedure. Ixocarpalactone A was detected in the fresh fruits (tomatillos) of P. Philadelphica by LC-MS-MS analysis at a concentration of 143 ± 4.53 ppb.
机译：生物活性指导下寻找新颖的，植物来源的癌症化学预防剂的结果是，ixocarpalactone A（5）先前已作为一种有效的醌还原酶诱导剂从from酸的叶子和茎中分离出来。在本研究中，这种有前途的铅化合物以克量重新分离出来，用于体内生物学测试。在这项工作的过程中，还获得了另外四个次要的新withanolides，并对其进行了表征，分别是2,3-二氢-3β-甲氧基ixocarpalactone A（1），2,3-二氢-3β-甲氧基ixocarpalactone B（2），2 3-dihydroixocarpalactone B（3）和4β，7β，20R-三羟基-1-oxowitha-2,5-dien-22,26-olide（4）。但是，使用液相色谱（LC）-MS-MS确定化合物1和2为提取和分离过程中产生的假象。通过LC-MS-MS分析，在P. Philadelphica的新鲜水果（番茄）中检测到异果皮内酯A，浓度为143±4.53 ppb。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号