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首页> 外文期刊>Pancreatology: official journal of the International Association of Pancreatology (IAP) ... [et al.] >FOXP3+ regulatory T cells and tumoral indoleamine 2,3-dioxygenase expression predicts the carcinogenesis of intraductal papillary mucinous neoplasms of the pancreas.
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FOXP3+ regulatory T cells and tumoral indoleamine 2,3-dioxygenase expression predicts the carcinogenesis of intraductal papillary mucinous neoplasms of the pancreas.

机译：FOXP3 +调节性T细胞和肿瘤吲哚胺2，3-二加氧酶的表达预示着胰腺导管内乳头状黏液性肿瘤的致癌作用。

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BACKGROUND AND AIMS: FOXP3+ regulatory T cells (Tregs) play a central role in self-tolerance and suppress the effective antitumor immune response. A recent study revealed that indoleamine 2,3-dioxygenase (IDO)-mediated tryptophan depletion was able to affect local tumor-infiltrating lymphocytes. The aim of this study was to investigate the clinical significance of the tumor-infiltrating Tregs and tumoral IDO expression during the progression of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas. METHODS: We investigated the prevalence and localization of FOXP3+ Tregs, CD8+ lymphocytes, and IDO expression in IPMNs by immunohistochemistry. We recruited 39 cases with IPMNs (IPMA: adenoma, n = 11; IPMB: borderline malignancy, n = 9; IPMC: noninvasive carcinoma, n = 7; I-IPMC: invasive IPMC, n = 12). RESULTS: The prevalence of Tregs increased step by step during the carcinogenesis of IPMNs (Kruskal-Wallis test: p < 0.0001). IDO expression in the tumor was observed in 5 cases with IPMNs (IPMC, n = 1; I-IPMC, n = 4). IDO expression in the tumor was positively correlated with the prevalence of Tregs in IPMNs. CONCLUSIONS: FOXP3+ Tregs play a role in controlling the immune surveillance against IPMNs at the premalignant stage. IDO expression in the tumor is one of the late-stage phenomena of multistage carcinogenesis of IPMNs.
机译：背景与目的：FOXP3 +调节性T细胞（Tregs）在自我耐受中起着核心作用，并抑制有效的抗肿瘤免疫反应。最近的一项研究表明，吲哚胺2，3-二加氧酶（IDO）介导的色氨酸耗竭能够影响局部肿瘤浸润淋巴细胞。这项研究的目的是调查胰腺导管内乳头状粘液性肿瘤（IPMNs）进程中肿瘤浸润的Treg和IDO表达的临床意义。方法：我们通过免疫组织化学方法研究了IPXPs中FOXP3 + Tregs，CD8 +淋巴细胞和IDO的表达和分布。我们招募了39例IPMN（IPMA：腺瘤，n = 11; IPMB：边缘性恶性肿瘤，n = 9; IPMC：非浸润性癌，n = 7; I-IPMC：浸润性IPMC，n = 12）。结果：在IPMNs的致癌过程中，Tregs的发生率逐步增加（Kruskal-Wallis检验：p <0.0001）。在5例IPMN中观察到IDO在肿瘤中的表达（IPMC，n = 1; I-IPMC，n = 4）。肿瘤中IDO的表达与IPMNs中Treg的表达呈正相关。结论：FOXP3 + Treg在癌变前阶段在控制针对IPMN的免疫监视中发挥作用。 IDO在肿瘤中的表达是IPMNs多阶段癌变的晚期现象之一。

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