...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biological chemistry >The role of Her2 and other oncogenes of the PI3K/AKT pathway in mitochondria
【24h】

The role of Her2 and other oncogenes of the PI3K/AKT pathway in mitochondria

机译：Her2和其他PI3K / AKT途径癌基因在线粒体中的作用

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Altered metabolism and resistance to cell death are typical hallmarks of cancer phenotype. Mitochondria are organelles central to cellular metabolism as well as to cell death induction. Hyperactivation of pro-survival and pro-proliferative pathways such as PI3K/AKT leads to cancer initiation, which affects mitochondria. Growing body of evidence indicates that oncogenes such as HER2, EGFR and RAS, as well as the downstream members of the PI3K/AKT signaling pathway, directly regulate mitochondria by translocating to the organelle. Here we discuss evidence of this scenario and consider mechanisms for direct regulation of mitochondrial function. Being in close proximity to mitochondrial bioenergetics machinery as well as to the regulators/executors of programed cell death, oncogenes in mitochondria may be ideally placed to perform this task. This represents a thus far under-explored area, which may be relevant to better understanding of cancer initiation, progression and treatment.
机译：代谢改变和对细胞死亡的抗性是癌症表型的典型标志。线粒体是细胞代谢以及细胞死亡诱导的核心细胞器。存活和增殖途径如PI3K / AKT的过度激活会导致癌症的发生，从而影响线粒体。越来越多的证据表明，癌基因（例如HER2，EGFR和RAS）以及PI3K / AKT信号通路的下游成员，通过转移到细胞器来直接调节线粒体。在这里，我们讨论这种情况的证据，并考虑直接调节线粒体功能的机制。与线粒体生物能学机制以及程序性细胞死亡的调控者/执行者非常接近，线粒体中的癌基因可能是理想的位置。这代表了迄今尚未充分探索的领域，可能与更好地了解癌症的发生，发展和治疗有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号