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首页> 外文期刊>Pancreatology: official journal of the International Association of Pancreatology (IAP) ... [et al.] >Autophagy and pancreas disease.
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Autophagy and pancreas disease.

机译：自噬和胰腺疾病。

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摘要

Autophagy is an evolutionarily preserved degradation process of cytoplasmic cellular constituents, which has been known for its role in protecting cells against stresses such as starvation and in eliminating defective subcellular structures. It is essentially a form of self-cannibalism - hence the name that means 'self-eating' - in which the cell breaks down its own components. By mostly morphological studies, autophagy has been linked to a variety of pathological processes such as neurodegenerative diseases and tumorigenesis, which highlights its biological and medical importance. However, whether autophagy protects from or causes disease is unclear. Autophagic morphology was described in human pancreatitis by Helin et al. in 1980. Actually, acute pancreatitis is one of the earlier pathological processes where autophagy has been described in a human tissue. Autophagy, autodigestion and cell death are early cellular events in acute pancreatitis. The aim of this review is to introduce a description of the autophagic process and to discuss the possible role of autophagy in acute pancreatitis.
机译：自噬是细胞质细胞组成的进化保留的降解过程，以其在保护细胞免受应激（例如饥饿）和消除有缺陷的亚细胞结构中的作用而闻名。它本质上是一种自相残杀的形式-因此这个名字的意思是“自食”-细胞会分解自身的成分。通过大多数形态学研究，自噬与多种病理过程相关，例如神经退行性疾病和肿瘤发生，这突出了其生物学和医学重要性。但是，自噬是否能预防或引起疾病尚不清楚。 Helin等人在人胰腺炎中描述了自噬形态。 1980年，急性胰腺炎实际上是人体组织中自噬被描述的早期病理过程之一。自噬，自消化和细胞死亡是急性胰腺炎的早期细胞事件。本文的目的是介绍自噬过程，并讨论自噬在急性胰腺炎中的可能作用。

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