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首页> 外文期刊>Pain. >Pain measurement with evoked potentials: combination of subjective ratings, randomized intensities, and long interstimulus intervals produces a P300-like confound.
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Pain measurement with evoked potentials: combination of subjective ratings, randomized intensities, and long interstimulus intervals produces a P300-like confound.

机译：具有诱发电位的疼痛测量：主观评分，随机强度和较长的刺激间隔相结合会产生类似P300的混淆。

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Evoked potentials in response to painful stimuli have been studied as objective measures of pain. Bromm has advocated experimental conditions in which, (1) stimulus intensities are randomized, and (2) subjects rate each stimulus. However, a cognitive, i.e. information processing, 'late positive component' (LPC), e.g. the P300, may be elicited by these same conditions, whether or not the stimuli are painful. The LPC may overlap, and interfere with the measurement of, responses that are only seen with painful stimuli. We compared the LPC in two experimental protocols using ten subjects and electrical stimuli. In the 'Rating Protocol', shocks of different intensity levels were randomly presented and subjects rated the intensity of each stimulus. In the 'Oddball Standards Protocol', the same levels were used, but each was presented in a separate block of a single level. Stimuli were presented more rapidly and subjects had to push a button in response to occasional double shocks (oddball targets), but not to single shocks (oddball standards). The oddball targets served to direct subjects' attention to the stimuli, but only the evoked potential responses to the oddball standards were used for data analysis. To look at the difference between protocols, we computed a difference condition (Rating protocol responses minus Oddball Standards protocol responses) which we called Incremental activity. The Incremental LPC (average amplitudes from 350 to 650 ms) had a more parietal topography (amplitude at electrode Pz greater than at Cz) than the Oddball Standards LPC (Cz > Pz; protocol x electrode interaction P<0.001). This implies that the Rating Protocol LPC included P300-like activity. The parietal Incremental activity began as early as 250-350 ms after the stimulus in the responses to the most painful stimuli and therefore can confound the measurement of pain activity in the evoked potential.
机译：作为对疼痛的客观测量，已经研究了对疼痛刺激的诱发电位。 Bromm提倡实验条件，其中（1）刺激强度是随机的，（2）受试者对每种刺激进行评分。但是，认知，即信息处理，是“后期积极成分”（LPC），例如。无论刺激是否疼痛，都可以通过这些相同条件引发P300。 LPC可能会重叠，并干扰仅在疼痛刺激下才能看到的响应的测量。我们在两个实验方案中使用十个受试者和电刺激对LPC进行了比较。在“评分方案”中，随机提出了​​不同强度的电击，受试者对每种刺激的强度进行了评估。在“奇数球标准协议”中，使用了相同的级别，但每个级别都在一个单独的级别中显示。刺激呈现得更快，受试者不得不对偶发的两次电击（打靶）做出反应，而不是对单次电击（打靶标准）做出反应。奇数球的目标用来引导受试者对刺激物的注意力，但是只有对奇数球标准的诱发电位反应才用于数据分析。为了查看协议之间的差异，我们计算了一个差异条件（评分协议响应减去Oddball标准协议响应），我们称其为增量活动。与Oddball标准LPC相比，增量LPC（平均振幅从350到650 ms）具有更大的顶面形貌（电极Pz处的振幅大于Cz处）（Cz> Pz;协议x电极相互作用P <0.001）。这意味着评级协议LPC包含类似P300的活动。顶壁增量活动最早在刺激后250-350毫秒开始对最痛苦的刺激做出反应，因此可以将诱发电位中疼痛活动的测量结果混淆。

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