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首页> 外文期刊>Pain. >Pain and allodynia/hyperalgesia induced by intramuscular injection of serotonin in patients with fibromyalgia and healthy individuals.
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Pain and allodynia/hyperalgesia induced by intramuscular injection of serotonin in patients with fibromyalgia and healthy individuals.

机译：肌注肌痛患者和健康个体肌肉注射5-羟色胺引起的疼痛和异常性疼痛/痛觉过敏。

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The aim of this study was to investigate the effect of injection of serotonin (5-HT) into the masseter muscle on pain and allodynia/hyperalgesia. Twelve female patients with fibromyalgia (FM) and 12 age-matched female healthy individuals (HI) participated in the study. The current pain intensity (CPI) and the pressure pain threshold (PPT) of the superficial masseter muscles were assessed bilaterally. 5-HT in one of three randomized concentrations (10(-3), 10(-5), 10(-7) M) or isotonic saline was then injected into either of the two masseter muscles in a double-blind manner. After the injections the CPI and PPT were recorded ten times during 30 min. The injections were repeated twice with the other concentrations of 5-HT after 1 and 2 weeks, respectively. In the FM-group there was a non-significant increase of CPI after injection that lasted during the entire 30-min period irrespective of whether 5-HT or saline was injected. Neither did the PPT change significantly. In the HI-group pain developed significantly after injection irrespective of whether 5-HT or saline was injected, but significantly more so after 5-HT at 10(-3) M than saline injection. CPI decreased quickly and then remained on a very low level for most of the experiment. 5-HT at both 10(-5) M and 10(-3) M caused a significantly greater decrease of PPT than saline. In conclusion, our results show that 5-HT injected into the masseter muscle of healthy female subjects elicits pain and allodynia/hyperalgesia, while no such responses occur in patients with fibromyalgia.
机译：这项研究的目的是调查在咬肌中注射5-羟色胺（5-HT）对疼痛和异常性疼痛/痛觉过敏的影响。十二名女性纤维肌痛（FM）患者和12位年龄相匹配的女性健康个体（HI）参与了该研究。双侧评估浅表咬肌的当前疼痛强度（CPI）和压力疼痛阈值（PPT）。然后以双盲方式将三种随机浓度之一的5-HT（10（-3），10（-5），10（-7）M）或等渗盐水注入到两个咬肌中的任一个中。注射后，在30分钟内记录CPI和PPT十次。分别在1周和2周后，以其他浓度的5-HT重复注射两次。在FM组中，注射后CPI的无明显增加，持续了整个30分钟的时间，而与注射5-HT或盐水无关。 PPT也没有明显变化。在HI组中，无论注射5-HT还是注射生理盐水，疼痛均在注射后显着发展，但是在10（-3）M注射5-HT后的疼痛明显大于注射生理盐水。在大多数实验中，CPI迅速下降，然后保持在非常低的水平。 10（-5）M和10（-3）M处的5-HT导致PPT的降低明显大于生理盐水。总之，我们的结果表明，向健康女性受试者的咬肌中注射5-HT会引起疼痛和异常性疼痛/痛觉过敏，而在纤维肌痛患者中则不会发生这种反应。

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