...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pain. >Noxious stimulation in children receiving general anaesthesia evokes an increase in delta frequency brain activity.
【24h】

Noxious stimulation in children receiving general anaesthesia evokes an increase in delta frequency brain activity.

机译：接受全身麻醉的儿童中的有害刺激引起大脑活动频率增加。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

More than 235,000children/year in the UK receive general anaesthesia, but it is unknown whether nociceptive stimuli alter cortical brain activity in anaesthetised children. Time-locked electroencephalogram (EEG) responses to experimental tactile stimuli, experimental noxious stimuli, and clinically required cannulation were examined in 51 children (ages 1-12years) under sevoflurane monoanaesthesia. Based on a pilot study (n=12), we hypothesised that noxious stimulation in children receiving sevoflurane monoanaesthesia would evoke an increase in delta activity. This was tested in an independent sample of children (n=39), where a subset (n=11) had topical local anaesthetic applied prior to stimulation. A novel method of time-locking the stimuli to the EEG recording was developed using an event detection interface and high-speed camera. Clinical cannulation evoked a significant increase (34.2±8.3%) in delta activity (P=0.042), without concomitant changes in heart rate or reflex withdrawal, which was not observed when local anaesthetic was applied (P=0.30). Experimental tactile (P=0.012) and noxious (P=0.0099) stimulation also evoked significant increases in delta activity, but the magnitude of the response was graded with stimulus intensity, with the greatest increase evoked by cannulation. We demonstrate that experimental and clinically essential noxious procedures, undertaken in anaesthetised children, alter the pattern of EEG activity, that this response can be inhibited by local anaesthetic, and that this measure is more sensitive than other physiological indicators of nociception. This technique provides the possibility that sensitivity to noxious stimuli during anaesthesia could be investigated in other clinical populations.
机译：在英国，每年有超过235,000名儿童接受全身麻醉，但是尚不清楚伤害性刺激是否会改变麻醉儿童的皮质大脑活动。在七氟醚单麻醉下对51例儿童（1至12岁）检查了对实验触觉刺激，实验有害刺激和临床需要的插管的时间锁定脑电图（EEG）反应。基于一项前瞻性研究（n = 12），我们假设接受七氟醚单麻醉的儿童中的有害刺激会引起δ活性增加。这是在一个独立的儿童样本（n = 39）中进行测试的，其中一个子集（n = 11）在刺激之前应用了局部局麻药。使用事件检测界面和高速摄像头，开发了一种将刺激时间锁定到EEG记录的新方法。临床插管法可显着提高三角洲活动度（34.2±8.3％）（P = 0.042），而不会伴随心率变化或反射性撤退，而使用局部麻醉药则未观察到（P = 0.30）。实验性触觉（P = 0.012）和有害性（P = 0.0099）刺激也引起Delta活动的显着增加，但是响应的大小随刺激强度而定，插管引起的最大增加。我们证明在麻醉的儿童中进行的实验和临床上必不可少的有害程序会改变EEG活动的模式，这种反应可以被局部麻醉抑制，并且该措施比其他伤害性生理指标更敏感。该技术提供了可能在其他临床人群中研究麻醉期间对有害刺激的敏感性的可能性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号