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首页> 外文期刊>Pain. >Unpleasant odors increase pain processing in a patient with neuropathic pain: psychophysical and fMRI investigation.
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Unpleasant odors increase pain processing in a patient with neuropathic pain: psychophysical and fMRI investigation.

机译：难闻的气味会增加神经性疼痛患者的疼痛处理能力：心理物理学和功能磁共振成像研究。

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摘要

A 49-year old man with neuropathic pain in his right elbow, wrist and digits III-V of his hand reported that certain odors increased his pain by superimposing an electric shock-like pain to his already existing pain. Psychophysical testing revealed that the best predictor of pain exacerbation was odor unpleasantness. Functional magnetic resonance imaging (fMRI) showed increased activation following an unpleasant odor in pain related areas, including the thalamus, amygdala, insular and anterior cingulate cortices, with similar trends in primary somatosensory cortex hand/arm area. The increased pain and associated neural activations in response to unpleasant odors may be related to the phenomenon of synesthesia, to a rewiring of olfactory pathways onto pain pathways mimicking synesthesia or, to activation of the sympathetic nervous system.
机译：一名49岁的老人的右肘，腕部和手部III-V指骨患有神经性疼痛，他报告说，通过将类似电击的疼痛叠加到他已经存在的疼痛上，某些气味会加剧疼痛。心理物理测试显示，疼痛加重的最佳预测指标是气味不愉快。功能性磁共振成像（fMRI）显示，在与疼痛相关的区域（包括丘脑，杏仁核，岛状和前扣带状皮层）出现难闻的气味后，激活增强，主要体感皮层的手/臂区域也有类似的趋势。响应于难闻的气味而增加的疼痛和相关的神经激活可能与联觉现象，嗅觉通路重新布线至模仿联觉的疼痛通路或与交感神经系统活化有关。

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