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首页> 外文期刊>Pain. >Evidence of diffuse noxious inhibitory controls (DNIC) elicited by cold noxious stimulation in patients with provoked vestibulodynia.
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Evidence of diffuse noxious inhibitory controls (DNIC) elicited by cold noxious stimulation in patients with provoked vestibulodynia.

机译：激惹的前庭不速患者中冷有害刺激引起的弥散性有害抑制性对照（DNIC）的证据。

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Provoked vestibulodynia is a common cause of superficial dyspareunia in young women. Recent evidence has pointed out the importance of studying endogenous pain modulation in these women. An impairment of diffuse noxious inhibitory controls (DNIC) has been suggested in chronic pain conditions with a female predominance such as fibromyalgia and temporomandibular disorder. Our aim was to examine whether patients with provoked vestibulodynia and healthy women with or without combined oral contraceptives (COC) display a DNIC response to cold noxious stimulation. Twenty patients with provoked vestibulodynia not using COC, 20 healthy women on COC and 20 healthy women without COC were included and tested days 7-11 of their menstrual cycle. Pressure pain thresholds (PPTs) and pain ratings using VAS were measured on the arm and leg before and during a cold pressor test. A socio-medical questionnaire, the Hospital and Anxiety Depression Scale and the Short Form-36 were completed. The majority of the subjects in all three study groups significantly increased their PPTs during cold noxious stimulation indicating a DNIC response. The patients displayed lower PPTs compared to the healthy women. Depression, anxiety and bodily pain were more often reported by the patients. No differences related to the intake of COC were observed between the healthy women. In conclusion, women with provoked vestibulodynia as well as healthy women irrespective of COC status display a DNIC response indicating an endogenous pain inhibition. However, the results imply a systemic hypersensitivity in women with vestibulodynia with low general pain thresholds as compared to healthy women.
机译：引起的前庭不速动是年轻女性浅表性痛经的常见原因。最近的证据指出了研究这些女性内源性疼痛调节的重要性。已建议在以女性为主的慢性疼痛情况下，如纤维肌痛和颞下颌疾病，损害弥散性有害抑制控制（DNIC）。我们的目的是检查患有诱发性前庭痛觉的患者和有或没有联合口服避孕药（COC）的健康女性是否表现出对冷伤害性刺激的DNIC反应。包括20名未使用COC的激起前庭痛的患者，20名使用COC的健康女性和20名未使用COC的健康女性，并在其月经周期的第7-11天进行了测试。在冷压试验之前和过程中，在手臂和腿部测量了使用VAS的压力疼痛阈值（PPT）和疼痛等级。一份社会医学调查表，《医院和焦虑抑郁量表》和《 36号简表》已经完成。所有三个研究组中的大多数受试者在冷伤害性刺激期间显着增加了其PPT，表明DNIC反应。与健康女性相比，患者的PPT更低。患者更经常报告抑郁，焦虑和身体疼痛。健康女性之间未观察到与COC摄入量相关的差异。总之，患有前庭性运动异常的妇女以及健康妇女，无论COC状况如何，均会显示DNIC反应，表明内源性疼痛抑制。但是，该结果表明，与健康女性相比，前庭痛觉过敏的妇女全身疼痛阈值低。

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