Cancer pain: part 1: Pathophysiology; oncological, pharmacological, and psychological treatments: a perspective from the British Pain Society endorsed by the UK Association of Palliative Medicine and the Royal College of General Practitioners.

Raphael J; Ahmedzai S; Hester J; Urch C; Barrie J; Williams J; Farquhar Smith P; Fallon M; Hoskin P; Robb K; Bennett MI; Haines R; Johnson M; Bhaskar A; Chong S; Duarte R; Sparkes E

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Cancer pain: part 1: Pathophysiology; oncological, pharmacological, and psychological treatments: a perspective from the British Pain Society endorsed by the UK Association of Palliative Medicine and the Royal College of General Practitioners.

机译：癌痛：第1部分：病理生理学;肿瘤学，药理学和心理治疗：由英国姑息医学协会和皇家全科医师学会认可的英国疼痛学会的观点。

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OBJECTIVE: This discussion document about the management of cancer pain is written from the pain specialists' perspective in order to provoke thought and interest in a multimodal approach to the management of cancer pain, not just towards the end of life, but pain at diagnosis, as a consequence of cancer therapies, and in cancer survivors. It relates the science of pain to the clinical setting and explains the role of psychological, physical, interventional and complementary therapies in cancer pain. METHODS: This document has been produced by a consensus group of relevant health care professionals in the United Kingdom and patients' representatives making reference to the current body of evidence relating to cancer pain. In the first of two parts, pathophysiology, oncological, pharmacological, and psychological treatment are considered. CONCLUSIONS: It is recognized that the World Health Organization (WHO) analgesic ladder, while providing relief of cancer pain towards the end of life for many sufferers worldwide, may have limitations in the context of longer survival and increasing disease complexity. To complement this, it is suggested that a more comprehensive model of managing cancer pain is needed that is mechanism-based and multimodal, using combination therapies including interventions where appropriate, tailored to the needs of an individual, with the aim to optimize pain relief with minimization of adverse effects.

机译：目的：从疼痛专家的角度撰写有关癌症疼痛管理的讨论文档，以激发人们对癌症疼痛管理的多模式方法的思考和兴趣，不仅是生命的尽头，而且是诊断时的疼痛，癌症疗法以及癌症幸存者的结果。它把疼痛的科学与临床环境联系起来，并解释了心理，物理，介入和补充疗法在癌症疼痛中的作用。方法：本文件由英国相关卫生保健专业人员和患者代表的共识小组制作，参考了与癌症疼痛有关的最新证据。在两个部分的第一部分中，考虑了病理生理学，肿瘤学，药理学和心理治疗。结论：公认的是，世界卫生组织（WHO）止痛梯在为世界范围内许多患者的生命尽头减轻癌症疼痛的同时，在更长的生存期和不断增加的疾病复杂性的背景下可能存在局限性。为了补充这一点，建议需要一种基于机制和多模式的更全面的癌症疼痛管理模型，该模型应采用组合疗法，包括针对个人需求量身定制的干预措施，旨在通过以下方式优化疼痛缓解：最小化不良影响。

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《Pain medicine :》 |2010年第5期|共23页
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Raphael J; Ahmedzai S; Hester J; Urch C; Barrie J; Williams J; Farquhar Smith P; Fallon M; Hoskin P; Robb K; Bennett MI; Haines R; Johnson M; Bhaskar A; Chong S; Duarte R; Sparkes E;
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1. Cancer pain: part 1: Pathophysiology; oncological, pharmacological, and psychological treatments: a perspective from the British Pain Society endorsed by the UK Association of Palliative Medicine and the Royal College of General Practitioners. [J] . Raphael J, Ahmedzai S, Hester J, Pain medicine : . 2010,第5期

机译：癌痛：第1部分：病理生理学;肿瘤学，药理学和心理治疗：由英国姑息医学协会和皇家全科医师学会认可的英国疼痛学会的观点。
2. A consensus conference organised by the British Cardiac Society,the British Nuclear Cardiology Society and the British Nuclear Medicine Society,endorsed by the Royal College of Physicians of London and the Royal College of Radiologists [J] . S R. Underwood, C. Anagnostopoulos, M. Cerqueira, European journal of nuclear medicine . 2004,第2期

机译：由英国心脏学会，英国核心脏病学会和英国核医学学会组织的共识会议，由伦敦皇家内科医师学会和皇家放射科医师学会认可
3. Fractures, Dislocations and Sprains. By Philip Wiles, M.S.(Lond.), F.R.C.S.(Eng.), F.A.C.S., Honorary Consultant Orthopaedic Surgeon, the Middlesex Hospital. Past President, the British Orthopaedic Association; the Orthopaedic Section, the Royal Society of Medicine; and the Orthopaedic Section, the British Medical Association. Corresponding Member, the American Orthopaedic Association. Formerly Hunterian Professor, the Royal College of Surgeons of England; Lecturer in Orthopaedic Surgery, the University of London; Brigadier, Consultant Surgeon in the Army. British Treasurer, The Journal of Bone and Joint Surgery. 10 x 12? in. Pp. 67, with 519 figures. 1960. London: J. & A. Churchill Ltd. Price 27s. 6d [J] . F. W. Holdsworth The Journal of Bone and Joint Surgery. British VolumecBritish Orthopaedic Association , Australian Orthopaedic Association , Canadian Orthopaedic Association . . . [et al] . 1960,第4期

机译：骨折，脱臼和扭伤。米德尔塞克斯医院骨科名誉顾问外科医生，菲利普·威尔斯英国骨科协会前任主席;皇家医学会骨科;和英国医学协会骨科。美国骨科协会会员。英国皇家外科医学院前亨廷顿教授;伦敦大学骨外科讲师;准将，陆军顾问医生。英国司库，《骨与关节外科杂志》。 10 x 12？ in。Pp。 67位，有519位数字。 1960年。伦敦：J。＆A. Churchill Ltd.价格27s。 6天
4. New Trials in Pharmacological Treatment of Radicular Pain: Based on Pathophysiology [C] . S.J. Lee International Society of Physical and Rehabilitation Medicine . 2007

机译：基于病理生理学的药理治疗新试验
5. The symptom cluster of fatigue, pain and psychological distress and its impact on the quality of life in Chinese patients with breast cancer undergoing cancer treatment. [D] . So, Kwok-Wei. 2007

机译：中国正在接受癌症治疗的乳腺癌患者的疲劳，疼痛和心理困扰症状群及其对生活质量的影响。
6. Primary care summary of the British Thoracic Society Guidelines for the management of community acquired pneumonia in adults: 2009 update Endorsed by the Royal College of General Practitioners and the Primary Care Respiratory Society UK [O] . Mark L Levy, Ivan Le Jeune, Mark A Woodhead, 2010

机译：英国胸科学会成人社区获得性肺炎管理指南的初级保健摘要：2009年更新得到英国皇家全科医师学会和英国初级保健呼吸学会的认可
7. Cancer Pain: Part 1: Pathophysiology; Oncological, Pharmacological, and Psychological Treatments: A Perspective from the British Pain Society Endorsed by the UK Association of Palliative Medicine and the Royal College of General Practitioners [O] . Raphael, Jon, Ahmedzai, Sam, Hester, Joan, 2010

机译：癌痛：第1部分：病理生理学；肿瘤学，药理学和心理治疗：英国疼痛学会的观点，得到了英国姑息医学协会和皇家全科医生的认可

Cancer pain: part 1: Pathophysiology; oncological, pharmacological, and psychological treatments: a perspective from the British Pain Society endorsed by the UK Association of Palliative Medicine and the Royal College of General Practitioners.

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