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首页> 外文期刊>Parasitology >Reinfection studies of canine echinococcosis and role of dogs in transmission of Echinococcus multilocularis in Tibetan communities, Sichuan, China
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Reinfection studies of canine echinococcosis and role of dogs in transmission of Echinococcus multilocularis in Tibetan communities, Sichuan, China

机译：四川省藏族地区犬埃奇球菌病的再感染及狗在多叶棘球oc球菌传播中的作用

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SUMMARY In the eastern Tibetan plateau both human cystic and alveolar echinococcosis (AE) caused by infection with Echincoccus granulosus or Echinococcus multilocularis, respectively are highly endemic. The domestic dog plays a key role in zoonotic transmission in this region. Our primary objective was to investigate the role of domestic dogs in maintaining transmission of E. multilocularis in Shiqu county, Sichuan. A cohort of 281 dogs was followed up over one year after a single treatment with praziquantel followed by re-infection surveillance at 2, 5 and 12 months post-treatment. Faecal samples were tested by an Echinococcus genus-specific coproantigen ELISA and two species-specific copro-PCR tests. Total Echinococcus coproantigen prevalence in Shiqu at baseline was 21% and 9·6% after 2 months. E. multilocularis copro-PCR was positive in 11·2% of dogs before treatment (vs 3·6% with E. granulosus copro-DNA), 2·9% at 2 months post-treatment, and 0% at 5 month and 12 months. The results suggest that dogs may have the potential to maintain E. multilocularis transmission within local pastoral communities, and thus dog dosing could be an effective strategy to reduce transmission of E. multilocularis as well as E. granulosus in these co-endemic Tibetan communities.
机译：发明内容在青藏高原东部，由粒状棘球c或多叶棘球infection感染引起的人囊性和肺泡棘球cc病（AE）分别是高度流行的。家犬在该地区的人畜共患病传播中起着关键作用。我们的主要目的是调查家犬在维持四川石渠县多叶大肠杆菌传播中的作用。在用吡喹酮单次治疗后的一年中，对一组281只狗进行了随访，然后在治疗后2、5和12个月进行再次感染监测。粪便样品通过棘球E属特异性共原抗原ELISA和两种物种特异性copro-PCR试验进行检测。基线时，曲阜地区总棘球E原抗原发生率在2个月后为21％和9·6％。治疗前11.2％的狗多眼大肠杆菌copro-PCR阳性（v。granulosus copro-DNA比犬3.6％），治疗后2个月为2.9％，5个月时为0％， 12个月。结果表明，狗可能具有维持当地牧民社区内多眼肠埃希氏菌传播的潜力，因此，在这些共同流行的藏族社区中，狗的给药可能是减少多眼埃希氏菌和颗粒肠埃希氏菌传播的有效策略。

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