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Differential association between circulating testosterone and infection risk by several viruses in natural cat populations: a behavioural-mediated effect?

机译:天然猫种群中循环睾丸激素和几种病毒感染风险之间的差异关联:行为介导的作用?

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摘要

Testosterone is involved in the development and expression of physiological, morphological and behavioural traits. High levels are often associated with high infection risk and/or intensity, suggesting a trade-off between sexual traits and immunity. Classically invoked mechanisms are immunological or behavioural, i.e., testosterone increases susceptibility or resistance to parasites via an impact on immunity or modulates behaviours involved in parasite transmission. However, studies report contrasted patterns. Given its modes of action and the diversity of host-parasite interactions, testosterone should not act similarly on all interactions. To reduce host and context diversity, we studied 3 viruses in the same cat population: the aggressively transmitted Feline Immunodeficiency virus (FIV), and the Feline Calicivirus (FCV) and Herpesvirus (FHV) both transmitted during friendly contacts. Testosterone had a strong effect on the probability of being positive to FIV whereas its effect was significantly weaker on FCV and FHV. These findings demonstrate that testosterone can be differentially associated with parasites of the same type (viruses). The difference we observed was consistent with a behavioural-mediated effect (increased aggressiveness), supporting the idea that the testosterone effect on infection risk is at least partially driven by behavioural mechanisms in our system. Further investigations (e.g., individual immunity measures) are required to confirm this hypothesis.
机译:睾丸激素参与生理,形态和行为特征的发展和表达。高水平通常与高感染风险和/或强度有关,这表明在性状和免疫力之间进行权衡。经典地调用的机制是免疫的或行为的,即,睾丸激素通过影响免疫力或调节寄生虫传播所涉及的行为而增加了对寄生虫的敏感性或抵抗力。但是,研究报告了不同的模式。考虑到其作用方式和宿主-寄生虫相互作用的多样性,睾丸激素不应在所有相互作用中都发挥相似的作用。为了减少宿主和环境的多样性,我们研究了同一猫群中的3种病毒:积极传播的猫免疫缺陷病毒(FIV),猫杯状病毒(FCV)和疱疹病毒(FHV)都在友好接触中传播。睾丸激素对FIV阳性的可能性有很强的影响,而对FCV和FHV的影响则明显弱。这些发现表明,睾丸激素可以与相同类型的寄生虫(病毒)存在差异性关联。我们观察到的差异与行为介导的作用(侵略性增加)一致,支持以下观点:睾丸激素对感染风险的作用至少部分地由我们系统中的行为机制驱动。需要进一步的研究(例如,个体免疫措施)以确认该假设。

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