Plasmodial Hsp40 and Hsp70 chaperones: Current and future perspectives

PesceE.-R.; BlatchG.L.

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Plasmodial Hsp40 and Hsp70 chaperones: Current and future perspectives

机译：疟原虫热休克蛋白40和热休克蛋白70伴侣：当前和未来的观点。

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SUMMARY Plasmodium falciparum displays a large and remarkable variety of heat shock protein 40 family members (PfHsp40s). The majority of the PfHsp40s are poorly characterized, and although the functions of some of them have been suggested, their exact mechanism of action is still elusive and their interacting partners and client proteins are unknown. The P. falciparum heat shock protein 70 family members (PfHsp70s) have been more extensively characterized than the PfHsp40s, with certain members shown to function as molecular chaperones. However, little is known about the PfHsp70-PfHsp40 chaperone partnerships. There is mounting evidence that these chaperones are important not only in protein homoeostasis and cytoprotection, but also in protein trafficking across the parasitophorous vacuole (PV) and into the infected erythrocyte. We propose that certain members of these chaperone families work together to maintain exported proteins in an unfolded state until they reach their final destination. In this review, we critically evaluate what is known and not known about PfHsp40s and PfHsp70s.

机译：发明内容恶性疟原虫显示出大量且显着的多种热激蛋白40家族成员（PfHsp40s）。大多数PfHsp40s的特征较差，尽管已经提出了其中一些功能，但它们的确切作用机理仍然难以捉摸，它们的相互作用伴侣和客户蛋白尚不清楚。恶性疟原虫热激蛋白70家族成员（PfHsp70s）比PfHsp40s具有更广泛的特征，某些成员被证明具有分子伴侣的功能。但是，关于PfHsp70-PfHsp40伴侣伴侣的了解甚少。越来越多的证据表明，这些分子伴侣不仅在蛋白质的均质和细胞保护中起着重要的作用，而且在穿过寄生虫液泡（PV）进入被感染的红细胞中的蛋白质运输中也很重要。我们建议这些分子伴侣家族的某些成员共同努力，以保持出口蛋白处于未折叠状态，直到到达最终目的地。在这篇综述中，我们严格地评估了有关PfHsp40s和PfHsp70s的已知和未知信息。

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《Parasitology》 |2014年第9期|共10页
作者
PesceE.-R.; BlatchG.L.;
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正文语种 eng
中图分类寄生虫病;
关键词
Hsp40; Hsp70; malaria; molecular chaperones; Plasmodium falciparum;

机译：Hsp40;Hsp70;疟疾;分子伴侣;恶性疟原虫;

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1. Plasmodial Hsp40 and Hsp70 chaperones: Current and future perspectives [J] . PesceE.-R., BlatchG.L. Parasitology . 2014,第9期

机译：疟原虫热休克蛋白40和热休克蛋白70伴侣：当前和未来的观点。
2. Direct interactions between molecular chaperones heat-shock protein (Hsp) 70 and Hsp40: yeast Hsp70 Ssa1 binds the extreme C-terminal region of yeast Hsp40 Sis1. [J] . Qian X, Hou W, Zhengang L, The Biochemical Journal . 2002,第Pta1期

机译：分子伴侣热休克蛋白（Hsp）70和Hsp40之间的直接相互作用：酵母Hsp70 Ssa1结合酵母Hsp40 Sis1的极端C末端区域。
3. Direct interactions between molecular chaperones heat-shock protein (Hsp) 70 and Hsp40: yeast Hsp70 Ssa1 binds the extreme C-terminal region of yeast Hsp40 Sis1 [J] . Qian XG, Hou WB, Li ZG, The Biochemical Journal . 2002,第1期

机译：分子伴侣热休克蛋白（Hsp）70和Hsp40之间的直接相互作用：酵母Hsp70 Ssa1结合酵母Hsp40 Sis1的极端C末端区域
4. Designing for the future: Civil aviation and airline perspectives of the current and future air transportation system [C] . Stull Tim Integrated Communications Navigation and Surveillance Conference . 2010

机译：面向未来的设计：民用航空和航空公司对当前和未来航空运输系统的看法
5. Life in an affluent globalized city: Working age Singaporeans' current perspectives and future expectations [D] . D'Amuro, Kriston Thomas. 2014

机译：富裕的全球化城市中的生活：工作年龄新加坡人的当前观点和未来期望
6. Direct interactions between molecular chaperones heat-shock protein (Hsp) 70 and Hsp40: yeast Hsp70 Ssa1 binds the extreme C-terminal region of yeast Hsp40 Sis1. [O] . Xinguo Qian, Wenbo Hou, Li Zhengang, 2002

机译：分子伴侣热休克蛋白（Hsp）70和Hsp40之间的直接相互作用：酵母Hsp70 Ssa1结合酵母Hsp40 Sis1的C末端极端区域。
7. Direct interactions between molecular chaperones heat-shock protein (Hsp) 70 and Hsp40: yeast Hsp70 Ssa1 binds the extreme C-terminal region of yeast Hsp40 Sis1. [O] . Qian, Xinguo, Hou, Wenbo, Zhengang, Li, 2002

机译：分子伴侣热休克蛋白（Hsp）70和Hsp40之间的直接相互作用：酵母Hsp70 Ssa1结合酵母Hsp40 Sis1的C末端极端区域。

Plasmodial Hsp40 and Hsp70 chaperones: Current and future perspectives

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