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Strongyloides stercoralis larvae excretion patterns before and after treatment

机译：治疗前后强线虫类固醇幼虫的排泄方式

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SUMMARY The variability of larval excretion impedes the parasitological diagnosis of Strongyloides stercoralis in infected individuals. We assessed the number of larvae excreted per gram (LPG) stool in 219 samples from 38 infected individuals over 7 consecutive days before and in 470 samples from 44 persons for 21 consecutive days after ivermectin treatment (200 μg kg-1 BW). The diagnostic sensitivity of a single stool sample was about 75% for individuals with low-intensity infections (≤1 LPG) and increased to 95% for those with high-intensity infections (≥ 10 LPG). Doubling the number of samples examined per person increased sensitivity to more than 95%, even for low-intensity infections. There was no indication of a cyclic excretion of larvae. After treatment, all individuals stopped excreting larvae within 3 days. Larvae were not detected during any of the following 18 days (total 388 Baermann and 388 Koga Agar tests). Two stool samples, collected on consecutive days, are recommended in settings where low or heterogeneous infection intensities are likely. In this way, taking into account the possible biological variability in excretion, the efficacy of ivermectin treatment can be assessed as soon as 4 days after treatment.
机译：发明内容幼虫排泄的可变性阻碍了感染个体中硬体类圆线虫的寄生虫学诊断。我们在伊维菌素治疗（200μgkg-1 BW）后连续21天评估了38个受感染个体的219个样本中每克（LPG）粪便排泄的幼虫数量，并连续21天对来自44个人的470个样本进行了21天连续性排泄。对于低强度感染（≤1 LPG）的患者，单个粪便样本的诊断敏感性约为75％，对于高强度感染（≥10 LPG）的患者，诊断敏感性提高至95％。即使对于低强度感染，每人检查的样本数量加倍也将敏感性提高到95％以上。没有迹象表明幼虫有周期性排泄。治疗后，所有个体均在3天内停止排泄幼虫。在接下来的18天中未检测到幼虫（总共进行了388 Baermann和388 Koga Agar测试）。建议在可能出现低或不同感染强度的环境中连续采集两份粪便样本。这样，考虑到排泄物中可能的生物学变异性，伊维菌素治疗的疗效可在治疗后4天进行评估。

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