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首页> 外文期刊>Parasitology >Genistein from Flemingia vestita (Fabaceae) enhances NO and its mediator (cGMP) production in a cestode parasite, Raillietina echinobothrida.
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Genistein from Flemingia vestita (Fabaceae) enhances NO and its mediator (cGMP) production in a cestode parasite, Raillietina echinobothrida.

机译：来自Flemingiavesita（Fabaceae）的金雀异黄素可增强c的寄生虫Raillietina echinobothrida中的NO及其介体（cGMP）的产生。

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摘要

Cyclic GMP (cGMP) is responsible for various cellular functions including signal pathways and it acts as a mediator for nitric oxide (NO). In order to evaluate the anthelmintic efficacy of the plant-derived isoflavones, the crude peel extract of Flemingia vestita and pure genistein were tested with respect to the activity of nitric oxide synthase (NOS), NO efflux and the cGMP concentration in Rallietina echinobothrida, the cestode parasite of domestic fowl. For comparison, the parasites were also treated with genistein (the major isoflavone present in the crude peel extract), sodium nitroprusside (SNP), a known NO donor, and praziquantel (PZQ), the reference drug. At the time of onset of paralysis in the parasite, the activity of NOS showed a significant increase (35-46%) and a 2-fold increase of NO efflux into the incubation medium in the treated worms in comparison to the respective controls. The cGMP concentration in the parasite tissue increased by 46-84% in the treated test worms in comparison to the controls. The results show that the isoflavones, genistein in particular, from the crude peel extract of F. vestita influence the cGMP concentration in the parasite tissue, which plays a major role in the downstream signal pathways.
机译：循环GMP（cGMP）负责各种细胞功能，包括信号通路，并充当一氧化氮（NO）的介质。为了评估植物异黄酮的驱虫效果，测试了弗莱明尼亚果和纯金雀异黄素的果皮提取物的一氧化氮合酶（NOS）活性，NO外排率和刺肠拟南芥（Rallietina echinobothrida）中cGMP的浓度。家禽的est虫寄生虫。为了进行比较，还用染料木黄酮（粗皮提取物中存在的主要异黄酮），已知的NO供体硝普钠（SNP）和参考药物吡喹酮（PZQ）处理了这些寄生虫。与相应的对照相比，在处理过的蠕虫中，寄生虫开始麻痹时，NOS的活性显示出显着增加（35-46％），NO流入培养液中的作用增加了2倍。与对照组相比，在处理过的测试蠕虫中，寄生虫组织中的cGMP浓度增加了46-84％。结果表明，异黄酮，特别是染料木黄酮，来自苦参提取物的粗皮提取物，会影响寄生虫组织中的cGMP浓度，这在下游信号通路中起主要作用。

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