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首页> 外文期刊>Parasitology >Evidence of an altered protective effect of metallothioneins after cadmium exposure in the digenean parasite-infected cockle (Cerastoderma edule).
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Evidence of an altered protective effect of metallothioneins after cadmium exposure in the digenean parasite-infected cockle (Cerastoderma edule).

机译：有证据表明，在第2种寄生虫感染的蛤中（Cerastoderma edule），镉暴露后金属硫蛋白的保护作用发生了改变。

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摘要

The aim of the present study was to analyse the relation between parasitism and subsequent metallothioneins (MT) in the case of metal contamination. Experimental exposure of parasitized and unparasitized cockles (Cerastoderma edule) to cadmium (Cd) was performed, with the cockle as first or second intermediate host of 2 digenean species. After 7 days of Cd exposure in microcosms, cockles infected as first intermediate host by Labratrema minimus exhibited metal concentrations in tissues double that in uninfected cockles. Jointly, MT concentrations of parasitized cockles were not modified in comparison with uninfected individuals in which concentrations were increased 4.3-fold compared with controls. In cockles experimentally infected as the second intermediate host by Himasthla elongata, cadmium concentrations significantly increased again in parasitized cockles compared with uninfected individuals in contaminated conditions. Simultaneously, MT concentrations in healthy cockles increased, whereas they significantly decreased in parasitized individuals. Therefore, the presence of digenean parasites in Cd-exposed cockles leads to a maintenance or a decrease in MT concentrations compared with healthy individuals, whereas Cd accumulation in tissues is significantly increased. These experiments indicate a significant alteration of the protective effect of metallothioneins towards metals which could consequently enhance cockle vulnerability. Moreover, these results highlight the limit of the use of MT as a biomarker of metal pollution in field monitoring if parasitism is not taken into account.
机译：本研究的目的是分析金属污染情况下寄生虫病与随后的金属硫蛋白（MT）之间的关系。进行了寄生和未寄生的鸟蛤（Cerastoderma edule）暴露于镉（Cd）的实验，该鸟蛤是2个双基因种的第一或第二中间宿主。在微观环境中暴露Cd 7天后，被最小的Labratrema minimus作为第一中间宿主感染的鸟蛤在组织中的金属浓度是未感染鸟蛤的两倍。总的来说，与未感染个体相比，被寄生虫的蛤的MT浓度没有改变，未感染个体的MT浓度比对照组增加了4.3倍。在实验中被伸长的希马斯拉虫感染作为第二中间宿主的鸟蛤中，与未感染个体相比，在受污染的条件下，被寄生的鸟蛤中的镉浓度再次显着增加。同时，健康鸟蛤中的MT浓度增加，而被寄生的个体中的MT浓度则显着下降。因此，与健康个体相比，暴露于Cd的鸟蛤中双基因寄生虫的存在导致MT浓度的维持或降低，而组织中Cd的积累显着增加。这些实验表明金属硫蛋白对金属的保护作用发生了显着改变，从而可能提高鸟蛤的脆弱性。此外，如果不考虑寄生性，这些结果突出了在野外监测中将MT用作金属污染生物标志物的局限性。

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