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首页> 外文期刊>Parasitology >Investigation of the morphological diversity of the potentially zoonotic Trypanosoma copemani in quokkas and Gilbert's potoroos
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Investigation of the morphological diversity of the potentially zoonotic Trypanosoma copemani in quokkas and Gilbert's potoroos

机译：在短尾和吉尔伯特波罗虫中潜在人畜共患的锥虫锥虫的形态多样性研究

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摘要

Trypanosomes are blood-borne parasites that can cause severe disease in both humans and animals, yet little is known of the pathogenicity and life-cycles of trypanosomes in native Australian mammals. Trypanosoma copemani is known to be infective to a variety of Australian marsupials and has recently been shown to be potentially zoonotic as it is resistant to normal human serum. In the present study, in vivo and in vitro examination of blood and cultures from Australian marsupials was conducted using light microscopy, immunofluorescence, scanning electron microscopy and fluorescence in situ hybridization. Promastigote, sphaeromastigote and amastigote life-cycle stages were detected in vivo and in vitro. Novel trypanosome-like stages were also detected both in vivo and in vitro representing an oval stage, an extremely thin stage, an adherent stage and a tiny round stage. The tiny round and adherent stages appeared to adhere to erythrocytes causing potential haematological damage with clinical effects similar to haemolytic anaemia. The present study shows for the first time that trypomastigotes are not the only life-cycle stages circulating within the blood stream of trypanosome infected Australian native marsupials and provides insights into possible pathogenic mechanisms of this potentially zoonotic trypanosome species.
机译：锥虫是血液传播的寄生虫，可在人类和动物中引起严重的疾病，但对于锥虫在澳大利亚本土哺乳动物中的致病性和生命周期知之甚少。已知锥虫锥虫可感染多种澳大利亚有袋动物，近来已被证明具有潜在的人畜共患病性，因为它对正常人血清具有抵抗力。在本研究中，使用光学显微镜，免疫荧光，扫描电子显微镜和荧光原位杂交对澳大利亚有袋动物的血液和培养物进行了体内和体外检查。在体内和体外均检测了前鞭毛体，鞭毛鞭毛体和鞭毛体的生命周期阶段。在体内和体外也检测到新的类锥虫样阶段，分别代表卵圆形阶段，极薄阶段，粘附阶段和微小圆形阶段。微小的圆形和粘附阶段似乎粘附在红细胞上，引起潜在的血液学损害，临床效果类似于溶血性贫血。本研究首次表明，锥虫不是在受锥虫感染的澳大利亚本土有袋动物的血液中循环的唯一生命周期阶段，并提供了对该潜在人畜共患锥虫物种可能的致病机制的见解。

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