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Cutaneous Leishmaniasis in dogs: is high seroprevalence indicative of a reservoir role?

机译：狗的皮肤利什曼病：较高的血清阳性率是否预示着水库的作用？

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摘要

American cutaneous leishmaniasis (ACL) is a complex disease with a rich diversity of animal host species. This diversity imposes a challenge, since understanding ACL transmission requires the adequate identification of reservoir hosts, those species able to be a source of additional infections. In this study we present results from an ACL cross-sectional serological survey of 51 dogs (Canis familiaris), where we used diagnostic tests that measure dog's exposure to Leishmania spp. parasites. We did our research in Panama, at a village that has undergone significant ecosystem level transformations. We found an ACL seroprevalence of 47% among dogs, and their exposure was positively associated with dog age and abundance of sand fly vectors in the houses of dog owners. Using mathematical models, which were fitted to data on the proportion of positive tests as function of dog age, we estimated a basic reproductive number (R-0 +/- S.E.) of 1.22 +/- 0.09 that indicates the disease is endemically established in the dogs. Nevertheless, this information by itself is insufficient to incriminate dogs as ACL reservoirs, given the inability to find parasites (or their DNA) in seropositive dogs and previously reported failures to experimentally infect vectors feeding on dogs with ACL parasites.
机译：美国皮肤利什曼病（ACL）是一种复杂的疾病，具有多种动物宿主物种。这种多样性带来了挑战，因为了解ACL传播需要充分识别储层宿主，那些物种可能成为其他感染源。在这项研究中，我们介绍了对51只狗（犬似犬）进行ACL横断面血清学调查的结果，其中我们使用了诊断测试来测量狗对利什曼原虫的接触。寄生虫。我们在巴拿马的一个生态系统水平发生重大变化的村庄进行了研究。我们发现狗中的ACL血清阳性率为47％，并且它们的暴露与狗的年龄和狗主人家中沙蝇媒介的丰富度呈正相关。我们使用数学模型拟合了阳性测试比例随狗龄变化的数据，我们估计基本生殖数（R-0 +/- SE）为1.22 +/- 0.09，这表明该病是地方性流行的那些狗。然而，鉴于无法在血清阳性狗中找到寄生虫（或其DNA），并且以前报道过无法实验性感染以ACL寄生虫为食的狗的载体，因此该信息本身不足以使狗成为ACL的宿主。

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