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首页> 外文期刊>Biomaterials >TCP is hardly resorbed and not osteoconductive in a non-loading calvarial model.
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TCP is hardly resorbed and not osteoconductive in a non-loading calvarial model.

机译：在无负荷颅盖模型中，TCP几乎不被吸收，并且不具有骨传导性。

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摘要

Tricalciumphosphate (TCP) has been used as a ceramic bone substitute material in the orthopedic field as well as in craniofacial surgery. Some controversies exist concerning the osteoconductive potential of this material in different implantation sites. This study was designed to evaluate the biological response of calvarial bone towards TCP granules under non-loading conditions to assess the potential of TCP as a biodegredable and osteoconductive bone substitue material for the cranial vault. Full-thickness non-critical size defects were made bilaterally in the calvaria of 21 adult Wistar rats. One side was filled by TCP granules, the contralateral side was left empty and used as a control. Animals were sacrified in defined time intervals up to 6 months. Bone regeneration was analyzed with special respect toward the micromorphological and microanalytical features of the material-bone interaction by electron microscopy and electron diffraction analysis. Histologic examination revealed no TCP degradation even after 6 months of implantation. In contrast, a nearly complete bone regeneration of control defects was found after 6 months. At all times TCP was surrounded by a thin fibrous layer without presence of osteoblasts and features of regular mineralization. As far as degradation and substitution are concerned, TCP is a less favourable material tinder conditions of non-loading.
机译：磷酸三钙（TCP）在整形外科领域以及颅面外科手术中已用作陶瓷骨替代材料。关于该材料在不同植入部位的骨传导潜力存在一些争议。这项研究旨在评估颅骨在非负荷条件下对TCP颗粒的生物学反应，以评估TCP作为颅穹顶可生物降解和骨传导性骨替代材料的潜力。在21只成年Wistar大鼠的颅骨中双侧进行了全层非临界大小的缺损。 TCP颗粒填充一侧，对侧留空并用作对照。在规定的时间间隔内将动物处死至多6个月。通过电子显微镜和电子衍射分析，特别针对材料-骨相互作用的微观形态和微观分析特征来分析骨再生。组织学检查显示即使植入6个月后也没有TCP降解。相反，六个月后发现对照缺陷的骨骼几乎完全再生。在任何时候，TCP都被一层薄薄的纤维层所包围，没有成骨细胞的存在，并且没有定期矿化的特征。就降级和替代而言，TCP是非负载的不利条件。

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