• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Parasitology >The role of chemokines and their receptors during protist parasite infections
【24h】

The role of chemokines and their receptors during protist parasite infections

机译：趋化因子及其受体在原生生物寄生虫感染中的作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Protists are a diverse collection of eukaryotic organisms that account for a significant global infection burden. Often, the immune responses mounted against these parasites cause excessive inflammation and therefore pathology in the host. Elucidating the mechanisms of both protective and harmful immune responses is complex, and often relies of the use of animal models. In any immune response, leucocyte trafficking to the site of infection, or inflammation, is paramount, and this involves the production of chemokines, small chemotactic cytokines of approximately 8-10 kDa in size, which bind to specific chemokine receptors to induce leucocyte movement. Herein, the scientific literature investigating the role of chemokines in the propagation of immune responses against key protist infections will be reviewed, focussing on Plasmodium species, Toxoplasma gondii, Leishmania species and Cryptosporidium species. Interestingly, many studies find that chemokines can in fact, promote parasite survival in the host, by drawing in leucocytes for spread and further replication. Recent developments in drug targeting against chemokine receptors highlights the need for further understanding of the role played by these proteins and their receptors in many different diseases.
机译：原生生物是真核生物的不同集合，它们构成了巨大的全球感染负担。通常，针对这些寄生虫的免疫反应会引起过度的炎症，从而导致宿主发生病理。阐明保护性和有害免疫反应的机制很复杂，并且通常依赖于动物模型的使用。在任何免疫应答中，白细胞向感染或炎症部位的运输都是至关重要的，这涉及趋化因子的产生，趋化因子是大小约为8-10 kDa的小型趋化细胞因子，与特定的趋化因子受体结合以诱导白细胞运动。在此，将综述研究趋化因子在针对关键原生生物感染的免疫反应传播中的作用的科学文献，重点是疟原虫，弓形虫，利什曼原虫和隐孢子虫。有趣的是，许多研究发现趋化因子实际上可以通过吸引白细胞扩散和进一步复制来促进宿主体内的寄生虫存活。靶向趋化因子受体的药物的最新进展凸显了对这些蛋白质及其受体在许多不同疾病中所起的作用的进一步了解的必要性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号